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Reviewed (UniProtKB/Swiss-Prot)

Note: Proteins listed in ProtBank™ database are NOT off-the-shelf [catalog] proteins. Customized protein production request can be made for any protein in this database by clicking on the corresponding button under "Quick Quote". Please ensure sequence accuracy and/or make any necessary modifications prior to submitting your quote request

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Reviewed (UniProtKB/Swiss-Prot)


Name Gene Symbol Rec Full Name Protein Information Quick Quote  Price,
Turnaround
MYOC_MOUSE, Mus musculus (house mouse) Myoc Trabecular meshwork-induced glucocorticoid response protein Functions
wild_type
Starting from $1600,
4 weeks
Protein Domains
mutant
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Protein Names | ProteinIDs  | Organism | Gene Names  | GeneID | Genome Annotation(Ensembl) |  Protein Sequence | 
General annotation |  References | Order
Protein Names
Recommended name:
 Myocilin;
Alternative name(s):
 Trabecular meshwork-induced glucocorticoid response protein
Protein IDs
(Accession numbers)
UniProtKB
 O70624
NCBI RefSeq

NP_034995.3, NM_010865.3.
Organism
Latin Name/
(Common Name)
Mus musculus (Mouse).
Taxonomic Identifier (NCBI)
 10090
Gene Names
 Myoc [GenPool]
GeneID

17926
Genome
Annotation (Ensembl)

ENSMUST00000028020, ENSMUSP00000028020; ENSMUSG00000026697
Protein Sequence
 
SEQUENCE   490 AA;  55314 MW;  2F090571E97B0425 CRC64;
MPALHLLFLA CLVWGMGART AQFRKANDRS GRCQYTFTVA SPNESSCPRE DQAMSAIQDL
QRDSSIQHAD LESTKARVRS LESLLHQMTL GRVTGTQEAQ EGLQGQLGAL RRERDQLETQ
TRDLEAAYNN LLRDKSALEE EKRQLEQENE DLARRLESSS EEVTRLRRGQ CPSTQYPSQD
MLPGSREVSQ WNLDTLAFQE LKSELTEVPA SQILKENPSG RPRSKEGDKG CGALVWVGEP
VTLRTAETIA GKYGVWMRDP KPTHPYTQES TWRIDTVGTE IRQVFEYSQI SQFEQGYPSK
VHVLPRALES TGAVVYAGSL YFQGAESRTV VRYELDTETV KAEKEIPGAG YHGHFPYAWG
GYTDIDLAVD ESGLWVIYST EEAKGAIVLS KLNPANLELE RTWETNIRKQ SVANAFVICG
ILYTVSSYSS AHATVNFAYD TKTGTSKTLT IPFTNRYKYS SMIDYNPLER KLFAWDNFNM
VTYDIKLLEM
General annotation
Function
 May participate in the obstruction of fluid outflow in the trabecular meshwork.
Cofactor
Subunit structure
 Homodimer. Interacts with OLFM3.
Subcellular location

Rough endoplasmic reticulum. Secreted. Cell projection, cilium. Note=Located preferentially in the ciliary rootlet and basal body of the connecting cilium of photoreceptor cells, and in the rough endoplasmic reticulum. Also secreted.
Tissue specificity
 Expressed in ciliary body, iris, retina, trabecular network and sclera but not in lens or cornea. Also expressed strongly in skeletal muscle and weakly in heart, brain, testis, liver, kidney, thyroid and epididymis. No expression detected in embryo.
Induction
Domain
Post-translational modification

Palmitoylated (By similarity).
Involvement in disease

References

  • "Characterization of the murine TIGR/myocilin gene.";,Abderrahim H., Jaramillo-Babb V.L., Zhou Z., Vollrath D.;,Mamm. Genome 9:673-675(1998)., PubMeb:9680392 DOI:10.1007/s003359900844

  • "Characterization and comparison of the human and mouse GLC1A glaucomagenes.";,Fingert J.H., Ying L., Swiderski R.E., Nystuen A.M., Arbour N.C.,Alward W.L.M., Sheffield V.C., Stone E.M.;,Genome Res. 8:377-384(1998)., PubMeb:9548973

  • "Characterization of the mouse Myoc/Tigr gene.";,Tomarev S.I., Tamm E.R., Chang B.;,Biochem. Biophys. Res. Commun. 245:887-893(1998)., PubMeb:9588210 DOI:10.1006/bbrc.1998.8541

  • "Mouse myocilin (Myoc) gene expression in ocular tissues.";,Takahashi H., Noda S., Imamura Y., Nagasawa A., Kubota R., Mashima Y.,Kudoh J., Oguchi Y., Shimizu N.;,Biochem. Biophys. Res. Commun. 248:104-109(1998)., PubMeb:9675094 DOI:10.1006/bbrc.1998.8917

  • "Optimedin: a novel olfactomedin-related protein that interacts withmyocilin.";,Torrado M., Trivedi R., Zinovieva R., Karavanova I., Tomarev S.I.;,Hum. Mol. Genet. 11:1291-1301(2002)., PubMeb:12019210 DOI:10.1093/hmg/11.11.1291

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Protein Domain Databases | 3D Structure Database  | Sequence Annotation | Protein-protein Interaction Databases  | 
Binary Interactions | Enzyme and Pathway Databases |  Phylogenomic Database | Proteomics Database | 
Comparative Toxicogenomics Database | Order
Protein Domain Databases
InterPro

IPR003112, Olfac-like.
Gene3D
PANTHER
Pfam

PF02191, OLF; 1.
PRINTS
SUPFAM
PROSITE

PS51132, OLF; 1.
3D Structure
Database (PDB)
Entry
Method
Resolution (A)
Chain
Positions
PDBsum
Sequence
Annotation
Feature key
Position(s)
Length
Description
Signal sequence 1 - 18 18 Potential.
Polypeptide chain 19 - 490 472 Myocilin. /FTId=PRO_0000020086.
Domain 230 - 489 260 Olfactomedin-like.
Coiled-coil region 69 - 170 102 Potential.
Glycosylation site 43 1 N-linked (GlcNAc...) (Potential).
Disulfide bond 231 - 419 189 By similarity.
Natural variance 164 1 T -> A (in strain: BALB/cJ).
Protein-protein
Interaction
Databases
DIP
IntAct
MINT
STRING

O70624
Binary Interactions
With
Entry
#Exp.
IntAct
Enzyme and Pathway Databases
Pathway
Interaction DB
Reactome
Phylogenomic Database
HOVERGEN

HBG105662
InParanoid

O70624
OMA

RYKYSSM
OrthoDB

EOG40S0FR
Proteomics
Database (PRIDE)

O70624
Comparative
Toxicogenomics
Database (CTD)

4653
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Email: [email protected]
Phone: 1-877-436-7274 (Toll-Free) 1-732-885-9188
Fax: 1-732-210-0262