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Reviewed (UniProtKB/Swiss-Prot)

Note: Proteins listed in ProtBank™ database are NOT off-the-shelf [catalog] proteins. Customized protein production request can be made for any protein in this database by clicking on the corresponding button under "Quick Quote". Please ensure sequence accuracy and/or make any necessary modifications prior to submitting your quote request

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Reviewed (UniProtKB/Swiss-Prot)


Name Gene Symbol Rec Full Name Protein Information Quick Quote  Price,
Turnaround
O10S1_HUMAN, Homo sapiens (human) OR10S1 Olfactory receptor OR11-279 Functions
wild_type
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Protein Domains
mutant
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Protein Names | ProteinIDs  | Organism | Gene Names  | GeneID | Genome Annotation(Ensembl) |  Protein Sequence | 
General annotation |  References | Order
Protein Names
Recommended name:
 Olfactory receptor 10S1;
Alternative name(s):
 Olfactory receptor OR11-279
Protein IDs
(Accession numbers)
UniProtKB
 Q8NGN2
NCBI RefSeq

NP_001004474.1, NM_001004474.1.
Organism
Latin Name/
(Common Name)
Homo sapiens (Human).
Taxonomic Identifier (NCBI)
 9606
Gene Names
 OR10S1 [GenPool]
GeneID

219873
Genome
Annotation (Ensembl)

ENST00000360721, ENSP00000353947; ENSG00000196248
Protein Sequence
 
SEQUENCE   331 AA;  36501 MW;  50DA45E36CA595D6 CRC64;
MTSRSVCEKM TMTTENPNQT VVSHFFLEGL RYTAKHSSLF FLLFLLIYSI TVAGNLLILL
TVGSDSHLSL PMYHFLGHLS FLDACLSTVT VPKVMAGLLT LDGKVISFEG CAVQLYCFHF
LASTECFLYT VMAYDRYLAI CQPLHYPVAM NRRMCAEMAG ITWAIGATHA AIHTSLTFRL
LYCGPCHIAY FFCDIPPVLK LACTDTTINE LVMLASIGIV AAGCLILIVI SYIFIVAAVL
RIRTAQGRQR AFSPCTAQLT GVLLYYVPPV CIYLQPRSSE AGAGAPAVFY TIVTPMLNPF
IYTLRNKEVK HALQRLLCSS FRESTAGSPP P
General annotation
Function
 Odorant receptor (Potential).
Cofactor
Subunit structure
Subcellular location

Cell membrane; Multi-pass membrane protein.
Tissue specificity
Induction
Domain
Post-translational modification

Involvement in disease

References

  • "Genome-wide discovery and analysis of human seven transmembrane helixreceptor genes.";,Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;,Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.

  • "Human chromosome 11 DNA sequence and analysis including novel geneidentification.";,Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F.,Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E.,FitzGerald M.G., Jaffe D.B., LaButti K., Nicol R., Park H.-S.,Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W.,Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S.,Sakaki Y.;,Nature 440:497-500(2006).,PubMeb:16554811 DOI:10.1038/nature04632

  • "The status, quality, and expansion of the NIH full-length cDNAproject: the Mammalian Gene Collection (MGC).";,Genome Res. 14:2121-2127(2004).,PubMeb:15489334 DOI:10.1101/gr.2596504

  • "DEFOG: a practical scheme for deciphering families of genes.";,Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,Lehrach H., Lancet D., Shamir R.;,Genomics 80:295-302(2002)., PubMeb:12213199 DOI:10.1006/geno.2002.6830

  • "The human olfactory receptor gene family.";,Malnic B., Godfrey P.A., Buck L.B.;,Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).,PubMeb:14983052 DOI:10.1073/pnas.0307882100

  • Malnic B., Godfrey P.A., Buck L.B.;,Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).

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Binary Interactions | Enzyme and Pathway Databases |  Phylogenomic Database | Proteomics Database | 
Comparative Toxicogenomics Database | Order
Protein Domain Databases
InterPro

IPR000276, 7TM_GPCR_Rhodpsn.

IPR017452, GPCR_Rhodpsn_supfam.

IPR000725, Olfact_rcpt.
Gene3D
PANTHER
Pfam

PF00001, 7tm_1; 1.
PRINTS

PR00237, GPCRRHODOPSN.

PR00245, OLFACTORYR.
SUPFAM
PROSITE

PS00237, G_PROTEIN_RECEP_F1_1; FALSE_NEG.

PS50262, G_PROTEIN_RECEP_F1_2; 1.
3D Structure
Database (PDB)
Entry
Method
Resolution (A)
Chain
Positions
PDBsum
Sequence
Annotation
Feature key
Position(s)
Length
Description
Polypeptide chain 1 - 331 331 Olfactory receptor 10S1. /FTId=PRO_0000150716.
Topological domain 1 - 38 38 Extracellular (Potential).
Topological domain 60 - 67 8 Cytoplasmic (Potential).
Topological domain 89 - 113 25 Extracellular (Potential).
Topological domain 135 - 153 19 Cytoplasmic (Potential).
Topological domain 175 - 211 37 Extracellular (Potential).
Topological domain 232 - 251 20 Cytoplasmic (Potential).
Topological domain 273 - 283 11 Extracellular (Potential).
Topological domain 305 - 331 27 Cytoplasmic (Potential).
Transmembrane region 39 - 59 21 Helical; Name=1; (Potential).
Transmembrane region 68 - 88 21 Helical; Name=2; (Potential).
Transmembrane region 114 - 134 21 Helical; Name=3; (Potential).
Transmembrane region 154 - 174 21 Helical; Name=4; (Potential).
Transmembrane region 212 - 231 20 Helical; Name=5; (Potential).
Transmembrane region 252 - 272 21 Helical; Name=6; (Potential).
Transmembrane region 284 - 304 21 Helical; Name=7; (Potential).
Glycosylation site 18 1 N-linked (GlcNAc...) (Potential).
Disulfide bond 111 - 203 93 By similarity.
Natural variance 63 1 G -> S (in dbSNP:rs17759513). /FTId=VAR_054358.
Natural variance 93 1 K -> R (in dbSNP:rs17686210). /FTId=VAR_054359.
Natural variance 112 1 A -> V (in dbSNP:rs17759447). /FTId=VAR_054360.
Protein-protein
Interaction
Databases
DIP
IntAct
MINT
STRING

Q8NGN2
Binary Interactions
With
Entry
#Exp.
IntAct
Enzyme and Pathway Databases
Pathway
Interaction DB
Reactome

REACT_14797, Signaling by GPCR.
Phylogenomic Database
HOVERGEN

HBG017625
InParanoid

Q8NGN2
OMA

VVSHFFL
OrthoDB

EOG4H72C4
Proteomics
Database (PRIDE)

Q8NGN2
Comparative
Toxicogenomics
Database (CTD)

219873
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