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Reviewed (UniProtKB/Swiss-Prot)

Note: Proteins listed in ProtBank™ database are NOT off-the-shelf [catalog] proteins. Customized protein production request can be made for any protein in this database by clicking on the corresponding button under "Quick Quote". Please ensure sequence accuracy and/or make any necessary modifications prior to submitting your quote request

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Reviewed (UniProtKB/Swiss-Prot)


Name Gene Symbol Rec Full Name Protein Information Quick Quote  Price,
Turnaround
OR8D4_HUMAN, Homo sapiens (human) OR8D4 Olfactory receptor OR11-275 Functions
wild_type
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Protein Domains
mutant
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Protein Names | ProteinIDs  | Organism | Gene Names  | GeneID | Genome Annotation(Ensembl) |  Protein Sequence | 
General annotation |  References | Order
Protein Names
Recommended name:
 Olfactory receptor 8D4;
Alternative name(s):
 Olfactory receptor OR11-275
Protein IDs
(Accession numbers)
UniProtKB
 Q8NGM9
NCBI RefSeq

NP_001005197.1, NM_001005197.1.
Organism
Latin Name/
(Common Name)
Homo sapiens (Human).
Taxonomic Identifier (NCBI)
 9606
Gene Names
 OR8D4 [GenPool]
GeneID

338662
Genome
Annotation (Ensembl)

ENST00000321355, ENSP00000325381; ENSG00000181518
Protein Sequence
 
SEQUENCE   314 AA;  35019 MW;  7D9AB003A8D3B0DA CRC64;
MGVKNHSTVT EFLLSGLTEQ AELQLPLFCL FLGIYTVTVV GNLSMISIIR LNRQLHTPMY
YFLSSLSFLD FCYSSVITPK MLSGFLCRDR SISYSGCMIQ LFFFCVCVIS ECYMLAAMAC
DRYVAICSPL LYRVIMSPRV CSLLVAAVFS VGFTDAVIHG GCILRLSFCG SNIIKHYFCD
IVPLIKLSCS STYIDELLIF VIGGFNMVAT SLTIIISYAF ILTSILRIHS KKGRCKAFST
CSSHLTAVLM FYGSLMSMYL KPASSSSLTQ EKVSSVFYTT VILMLNPLIY SLRNNEVRNA
LMKLLRRKIS LSPG
General annotation
Function
 Odorant receptor (Potential).
Cofactor
Subunit structure
Subcellular location

Cell membrane; Multi-pass membrane protein.
Tissue specificity
Induction
Domain
Post-translational modification

Involvement in disease

References

  • "Genome-wide discovery and analysis of human seven transmembrane helixreceptor genes.";,Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;,Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.

  • "The status, quality, and expansion of the NIH full-length cDNAproject: the Mammalian Gene Collection (MGC).";,Genome Res. 14:2121-2127(2004).,PubMeb:15489334 DOI:10.1101/gr.2596504

  • "The human olfactory receptor gene family.";,Malnic B., Godfrey P.A., Buck L.B.;,Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).,PubMeb:14983052 DOI:10.1073/pnas.0307882100

  • Malnic B., Godfrey P.A., Buck L.B.;,Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).

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Protein Domain Databases | 3D Structure Database  | Sequence Annotation | Protein-protein Interaction Databases  | 
Binary Interactions | Enzyme and Pathway Databases |  Phylogenomic Database | Proteomics Database | 
Comparative Toxicogenomics Database | Order
Protein Domain Databases
InterPro

IPR000276, 7TM_GPCR_Rhodpsn.

IPR017452, GPCR_Rhodpsn_supfam.

IPR000725, Olfact_rcpt.
Gene3D
PANTHER
Pfam

PF00001, 7tm_1; 1.
PRINTS

PR00237, GPCRRHODOPSN.

PR00245, OLFACTORYR.
SUPFAM
PROSITE

PS00237, G_PROTEIN_RECEP_F1_1; 1.

PS50262, G_PROTEIN_RECEP_F1_2; 1.
3D Structure
Database (PDB)
Entry
Method
Resolution (A)
Chain
Positions
PDBsum
Sequence
Annotation
Feature key
Position(s)
Length
Description
Polypeptide chain 1 - 314 314 Olfactory receptor 8D4. /FTId=PRO_0000150661.
Topological domain 1 - 25 25 Extracellular (Potential).
Topological domain 47 - 54 8 Cytoplasmic (Potential).
Topological domain 76 - 99 24 Extracellular (Potential).
Topological domain 121 - 139 19 Cytoplasmic (Potential).
Topological domain 161 - 197 37 Extracellular (Potential).
Topological domain 218 - 237 20 Cytoplasmic (Potential).
Topological domain 259 - 271 13 Extracellular (Potential).
Topological domain 293 - 314 22 Cytoplasmic (Potential).
Transmembrane region 26 - 46 21 Helical; Name=1; (Potential).
Transmembrane region 55 - 75 21 Helical; Name=2; (Potential).
Transmembrane region 100 - 120 21 Helical; Name=3; (Potential).
Transmembrane region 140 - 160 21 Helical; Name=4; (Potential).
Transmembrane region 198 - 217 20 Helical; Name=5; (Potential).
Transmembrane region 238 - 258 21 Helical; Name=6; (Potential).
Transmembrane region 272 - 292 21 Helical; Name=7; (Potential).
Glycosylation site 5 1 N-linked (GlcNAc...) (Potential).
Disulfide bond 97 - 189 93 By similarity.
Natural variance 55 1 L -> R (in dbSNP:rs17127947). /FTId=VAR_034257.
Natural variance 92 1 I -> V (in dbSNP:rs17127950). /FTId=VAR_034258.
Natural variance 120 1 C -> Y (in dbSNP:rs10750250). /FTId=VAR_053245.
Natural variance 133 1 R -> K (in dbSNP:rs7926767). /FTId=VAR_024118.
Natural variance 200 1 F -> L (in dbSNP:rs10790610). /FTId=VAR_024119.
Natural variance 205 1 F -> S (in dbSNP:rs12270203). /FTId=VAR_034259.
Natural variance 283 1 L -> P (in dbSNP:rs7942047). /FTId=VAR_024120.
Natural variance 298 1 R -> K (in dbSNP:rs7927385). /FTId=VAR_024121.
Protein-protein
Interaction
Databases
DIP
IntAct
MINT
STRING

Q8NGM9
Binary Interactions
With
Entry
#Exp.
IntAct
Enzyme and Pathway Databases
Pathway
Interaction DB
Reactome

REACT_14797, Signaling by GPCR.
Phylogenomic Database
HOVERGEN

HBG017625
InParanoid

Q8NGM9
OMA

FTDAMIH
OrthoDB

EOG4MGS80
Proteomics
Database (PRIDE)

Q8NGM9
Comparative
Toxicogenomics
Database (CTD)

338662
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