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Reviewed (UniProtKB/Swiss-Prot)

Note: Proteins listed in ProtBank™ database are NOT off-the-shelf [catalog] proteins. Customized protein production request can be made for any protein in this database by clicking on the corresponding button under "Quick Quote". Please ensure sequence accuracy and/or make any necessary modifications prior to submitting your quote request

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Reviewed (UniProtKB/Swiss-Prot)


Name Gene Symbol Rec Full Name Protein Information Quick Quote  Price,
Turnaround
PAX8_RAT, Rattus norvegicus (Norway rat) Pax8 Paired box protein Pax-8 Functions
wild_type
Starting from $1600,
4 weeks
Protein Domains
mutant
Quote

Protein Names | ProteinIDs  | Organism | Gene Names  | GeneID | Genome Annotation(Ensembl) |  Protein Sequence | 
General annotation |  References | Order
Protein Names
Recommended name:
 Paired box protein Pax-8;
Alternative name(s):
Protein IDs
(Accession numbers)
UniProtKB
 P51974
NCBI RefSeq

NP_112403.2, NM_031141.2.
Organism
Latin Name/
(Common Name)
Rattus norvegicus (Rat).
Taxonomic Identifier (NCBI)
 10116
Gene Names
 Pax8 [GenPool]
GeneID

81819
Genome
Annotation (Ensembl)

ENSRNOT00000019088, ENSRNOP00000019088; ENSRNOG00000026203
Protein Sequence
 
SEQUENCE   457 AA;  48806 MW;  50946E0829936D62 CRC64;
MPHNSIRSGH GGLNQLGGAF VNGRPLPEVV RQRIVDLAHQ GVRPCDISRQ LRVSHGCVSK
ILGRYYETGS IRPGVIGGSK PKVATPKVVE KIGDYKRQNP TMFAWEIRDR LLAEGVCDND
TVPSVSSINR IIRTKVQQPF NLPMDSCVAT KSLSPGHTLI PSSAVTPPES PQSDSLGSTY
SINGLLGIAQ PGSDNKRKMD DSDQDSCRLS IDSQSSSSGP RKHLRTDTFG QHHLEPLECP
FERQHYPEAY ASPSHTKGEQ GLYPLPLLNS TLDDGKATLT PSNTPLGRNL STHQTYPVVA
DPHSPYAIKQ ETPELSSSSS TPSSLSSSAF LDLQQVGSGG PAGASVPPFN AFSHAASVYG
QFTGQALLSG REMVGPTLPG YPPHIPTSGQ GSYASSAIAG MVAGSEYSGN AYSHTPYASY
SEAWRFPNSS LLSSPYYYSS TTRPSAPPTS ATAFDHL
General annotation
Function
 Thought to encode a transcription factor. It may have a role in kidney cell differentiation. May play a regulatory role in mammalian development (By similarity).
Cofactor
Subunit structure
 Interacts with WWTR1 (By similarity).
Subcellular location

Nucleus.
Tissue specificity
Induction
Domain
Post-translational modification

Involvement in disease

References

  • Zannini M.;,Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases.

  • "The status, quality, and expansion of the NIH full-length cDNAproject: the Mammalian Gene Collection (MGC).";,Genome Res. 14:2121-2127(2004).,PubMeb:15489334 DOI:10.1101/gr.2596504

  • "Quantitative phosphoproteomics of vasopressin-sensitive renal cells:regulation of aquaporin-2 phosphorylation at two sites.";,Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.;,Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006).,PubMeb:16641100 DOI:10.1073/pnas.0600895103

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Protein Domain Databases | 3D Structure Database  | Sequence Annotation | Protein-protein Interaction Databases  | 
Binary Interactions | Enzyme and Pathway Databases |  Phylogenomic Database | Proteomics Database | 
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Protein Domain Databases
InterPro

IPR009057, Homeodomain-like.

IPR001523, Paired_box_N.

IPR022130, Pax2_C.

IPR011991, WHTH_trsnscrt_rep_DNA-bd.
Gene3D

G3DSA:1.10.10.10, Wing_hlx_DNA_bd; 2.
PANTHER
Pfam

PF00292, PAX; 1.

PF12403, Pax2_C; 1.
PRINTS

PR00027, PAIREDBOX.
SUPFAM

SSF46689, Homeodomain_like; 1.
PROSITE

PS00034, PAIRED_1; 1.

PS51057, PAIRED_2; 1.
3D Structure
Database (PDB)
Entry
Method
Resolution (A)
Chain
Positions
PDBsum
Sequence
Annotation
Feature key
Position(s)
Length
Description
Polypeptide chain 1 - 457 457 Paired box protein Pax-8. /FTId=PRO_0000050199.
Domain 9 - 135 127 Paired.
Compositionally biased region 316 - 328 13 Ser-rich.
Posttranslational modification of a residue 280 1 Phosphothreonine.
Posttranslational modification of a residue 284 1 Phosphothreonine.
Different sources report differing sequences 183 1 N -> H (in Ref. 1; CAA63930).
Different sources report differing sequences 191 1 P -> A (in Ref. 1; CAA63930).
Different sources report differing sequences 195 - 199 5 NKRKM -> THRGRC (in Ref. 1; CAA63930).
Different sources report differing sequences 205 - 206 2 DS -> GQ (in Ref. 1; CAA63930).
Different sources report differing sequences 377 1 T -> S (in Ref. 1; CAA63930).
Protein-protein
Interaction
Databases
DIP
IntAct

P51974
MINT
STRING

P51974
Binary Interactions
With
Entry
#Exp.
IntAct
Nkx2-1P23441 2EBI-1223113, EBI-1223127
Wbp2Q8R478 3EBI-1223113, EBI-1223229
Enzyme and Pathway Databases
Pathway
Interaction DB
Reactome
Phylogenomic Database
HOVERGEN

HBG009115
InParanoid

P51974
OMA
OrthoDB

EOG42NJ0G
Proteomics
Database (PRIDE)
Comparative
Toxicogenomics
Database (CTD)

7849
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