Protein Annotations for Protocadherin alpha-C2, PCDC2

Home » Recombinant Protein & rAb Services » PROTBANK™ Protein Database

Name	Gene Symbol	Rec Full Name	Protein Information	Quick Quote	Price, Turnaround
PCDC2_HUMAN, Homo sapiens (human)	PCDHAC2	Protocadherin alpha-C2	Functions		Quote
PCDC2_HUMAN, Homo sapiens (human)	PCDHAC2	Protocadherin alpha-C2	Protein Domains		Quote

Protein Names

Recommended name:	Protocadherin alpha-C2;
Alternative name(s):

Protein IDs
(Accession numbers)

UniProtKB

Q9Y5I4

NCBI RefSeq

NP_061722.1, NM_018899.5.

NP_114089.1, NM_031883.2.

Organism

Latin Name/ (Common Name)	Homo sapiens (Human).
Taxonomic Identifier (NCBI)	9606

Gene Names

PCDHAC2 [GenPool]

GeneID

56134

Genome
Annotation (Ensembl)

ENST00000289269, ENSP00000289269; ENSG00000243232

Protein Sequence

SEQUENCE   1007 AA;  109450 MW;  39BF2356923E3B67 CRC64;
MEQAGTRPAA TEHPRLRRPM PWLLLLPLLL LLLLLLPGPA ASQLRYSVPE EQAPGALVGN
VARALGLELR RLGPGCLRIN HLGAPSPRYL ELDLTSGALF VNERIDREAL CEQRPRCLLS
LEVLAHNPVA VSAVEVEILD INDNSPRFPR PNYQLQVSES VAPGARFHIE SAQDPDVGAN
SVQTYELSPS EHFELDLKPL QENSKVLELV LRKGLDREQA ALHHLVLTAV DGGIPARSGT
AQISVRVLDT NDNSPAFDQS TYRVQLREDS PPGTLVVKLN ASDPDEGSNG ELRYSLSSYT
SDRERQLFSI DASTGEVRVI GGLDYEEASS YQIYVQATDR GPVPMAGHCK VLVDIVDVND
NAPEVVLTDL YSPVPENATP NTIVAVLSVN DQDSGPNRKV SLGLEATLPF RLNGFGNSYT
LVVSGPLDRE RVAVYNITVT ATDGGIPQLT SLRTLKVEIS DINDNPPSFL EDSYSIYIQE
NNLPGVLLCT VQATDPDEKE NAEVTYSLLE REIQGLPVTS YVSINSASGS LYAVNSFDYE
KFREFFVTVE AQDKGSPPLS STVTANVYVV DMNDHAPHIL YPTSTNSSAA FEMVPRTAPA
GYLVTKVIAM DSDSGQNAWL FYHLAQTSDL DLFKVELHTG EIRTTRKMGD ESGSTFNLTV
VVRDNGEPSL SASVAITVAV VDRVSKILPD TQRHVKSPRT YSEITLYLII ALSTVSFIFL
LTIIILSIIK CYRYTAYGTA CCGGFCGVRE RSPAELYKQA NNNIDARIPH GLKVQPHFIE
VRGNGSLTKT YCYKACLTAG SGSDTFMFYN TGAQTGPGPS GAQAAVTDSR NLTGQSGQNA
GNLIILKNEA VSQNEPRQPN PDWRYSASLR AGMHSSVHLE EAGILRAGPG GPDQQWPTVS
SATPEPEAGE VSPPVGAGVN SNSWTFKYGP GNPKQSGPGE LPDKFIIPGS PAIISIRQEP
TNSQIDKSDF ITFGKKEETK KKKKKKKGNK TQEKKEKGNS TTDNSDQ

General annotation

Function	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
Cofactor
Subunit structure
Subcellular location	Cell membrane; Single-pass type I membrane protein (By similarity).
Tissue specificity
Induction
Domain
Post-translational modification
Involvement in disease

References

"A striking organization of a large family of human neural cadherin-like cell adhesion genes.";,Wu Q., Maniatis T.;,Cell 97:779-790(1999)., PubMeb:10380929 DOI:10.1016/S0092-8674(00)80789-8
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,Venter J.C.;,Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
"The status, quality, and expansion of the NIH full-length cDNAproject: the Mammalian Gene Collection (MGC).";,Genome Res. 14:2121-2127(2004).,PubMeb:15489334 DOI:10.1101/gr.2596504

Order Custom
Gene & Protein

	Secured Online Quotation
	Email: [email protected]
	Phone: 1-877-436-7274 (Toll-Free) 1-732-885-9188
	Fax: 1-732-210-0262

Protein Domain Databases

InterPro	IPR002126, Cadherin. IPR015919, Cadherin-like. IPR020894, Cadherin_CS. IPR013164, Cadherin_N.
Gene3D	G3DSA:2.60.40.60, Cadherin; 6.
PANTHER
Pfam	PF00028, Cadherin; 5. PF08266, Cadherin_2; 1.
PRINTS	PR00205, CADHERIN.
SUPFAM	SSF49313, Cadherin; 6.
PROSITE	PS00232, CADHERIN_1; 5. PS50268, CADHERIN_2; 6.

3D Structure
Database (PDB)

Entry

Method

Resolution (A)

Chain

Positions

PDBsum

Sequence
Annotation

Feature key	Position(s)	Length	Description
Signal sequence	1 - 42	42	Potential.
Polypeptide chain	43 - 1007	965	Protocadherin alpha-C2. /FTId=PRO_0000003912.
Topological domain	43 - 708	666	Extracellular (Potential).
Topological domain	730 - 1007	278	Cytoplasmic (Potential).
Transmembrane region	709 - 729	21	Helical; (Potential).
Domain	43 - 148	106	Cadherin 1.
Domain	149 - 257	109	Cadherin 2.
Domain	258 - 365	108	Cadherin 3.
Domain	374 - 469	96	Cadherin 4.
Domain	470 - 579	110	Cadherin 5.
Domain	594 - 691	98	Cadherin 6.
Internal sequence repetition	856 - 859	4	PXXP 1.
Internal sequence repetition	889 - 892	4	PXXP 2.
Internal sequence repetition	930 - 933	4	PXXP 3.
Internal sequence repetition	948 - 951	4	PXXP 4.
Region	856 - 951	96	4 X 4 AA repeats of P-X-X-P.
Compositionally biased region	980 - 987	8	Poly-Lys.
Glycosylation site	280	1	N-linked (GlcNAc...) (Potential).
Glycosylation site	436	1	N-linked (GlcNAc...) (Potential).
Glycosylation site	586	1	N-linked (GlcNAc...) (Potential).
Glycosylation site	657	1	N-linked (GlcNAc...) (Potential).
Natural variance	856 - 884	29	PRQPNPDWRYSASLRAGMHSSVHLEEAGI -> VRQWSGGL /FTId=VSP_000701.
Natural variance	885 - 1007	123	Missing (in isoform Short). /FTId=VSP_000702.

Protein-protein
Interaction
Databases

DIP
IntAct
MINT
STRING	Q9Y5I4

Binary Interactions

With

Entry

#Exp.

IntAct

Enzyme and Pathway Databases

Pathway Interaction DB
Reactome

Phylogenomic Database

HOVERGEN	HBG054878
InParanoid	Q9Y5I4
OMA
OrthoDB	EOG4SN1N1

Proteomics
Database (PRIDE)

Q9Y5I4

Comparative
Toxicogenomics
Database (CTD)

56134

Order Your Custom Protein

	Secured Online Quotation
	Email: [email protected]
	Phone: 1-877-436-7274 (Toll-Free) 1-732-885-9188
	Fax: 1-732-210-0262

Resources

Support

Company

Shopping Tools