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Reviewed (UniProtKB/Swiss-Prot)

Note: Proteins listed in ProtBank™ database are NOT off-the-shelf [catalog] proteins. Customized protein production request can be made for any protein in this database by clicking on the corresponding button under "Quick Quote". Please ensure sequence accuracy and/or make any necessary modifications prior to submitting your quote request

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Reviewed (UniProtKB/Swiss-Prot)


Name Gene Symbol Rec Full Name Protein Information Quick Quote  Price,
Turnaround
PPARD_MOUSE, Mus musculus (house mouse) Ppard Peroxisome proliferator-activated receptor beta Functions
wild_type
Starting from $1600,
4 weeks
Protein Domains
mutant
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Protein Names | ProteinIDs  | Organism | Gene Names  | GeneID | Genome Annotation(Ensembl) |  Protein Sequence | 
General annotation |  References | Order
Protein Names
Recommended name:
 Peroxisome proliferator-activated receptor delta;
Alternative name(s):
 Nuclear hormone receptor 1
Nuclear receptor subfamily 1 group C member 2
Peroxisome proliferator-activated receptor beta
Protein IDs
(Accession numbers)
UniProtKB
 P35396
NCBI RefSeq

NP_035275.1, NM_011145.3.
Organism
Latin Name/
(Common Name)
Mus musculus (Mouse).
Taxonomic Identifier (NCBI)
 10090
Gene Names
 Ppard [GenPool]
GeneID

19015
Genome
Annotation (Ensembl)

ENSMUST00000002320, ENSMUSP00000002320; ENSMUSG00000002250
Protein Sequence
 
SEQUENCE   440 AA;  49715 MW;  58E0F595DD193FDA CRC64;
MEQPQEETPE AREEEKEEVA MGDGAPELNG GPEHTLPSSS CADLSQNSSP SSLLDQLQMG
CDGASGGSLN MECRVCGDKA SGFHYGVHAC EGCKGFFRRT IRMKLEYEKC DRICKIQKKN
RNKCQYCRFQ KCLALGMSHN AIRFGRMPEA EKRKLVAGLT ASEGCQHNPQ LADLKAFSKH
IYNAYLKNFN MTKKKARSIL TGKSSHNAPF VIHDIETLWQ AEKGLVWKQL VNGLPPYNEI
SVHVFYRCQS TTVETVRELT EFAKNIPNFS SLFLNDQVTL LKYGVHEAIF AMLASIVNKD
GLLVANGSGF VTHEFLRSLR KPFSDIIEPK FEFAVKFNAL ELDDSDLALF IAAIILCGDR
PGLMNVPQVE AIQDTILRAL EFHLQVNHPD SQYLFPKLLQ KMADLRQLVT EHAQMMQWLK
KTESETLLHP LLQEIYKDMY
General annotation
Function
 Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand (By similarity).
Cofactor
Subunit structure
 Heterodimer with the retinoid X receptor.
Subcellular location

Nucleus.
Tissue specificity
 Heart, adrenal and intestine.
Induction
Domain
Post-translational modification

Involvement in disease

References

  • "Cloning of a protein that mediates transcriptional effects of fattyacids in preadipocytes. Homology to peroxisome proliferator-activatedreceptors.";,Amri E.-Z., Bonino F., Ailhaud G., Abumrad N.A., Grimaldi P.A.;,J. Biol. Chem. 270:2367-2371(1995)., PubMeb:7836471 DOI:10.1074/jbc.270.5.2367

  • "Differential expression and activation of a family of murineperoxisome proliferator-activated receptors.";,Kliewer S.A., Forman B.M., Blumberg B., Ong E.S., Borgmeyer U.,Mangelsdorf D.J., Umesono K., Evans R.M.;,Proc. Natl. Acad. Sci. U.S.A. 91:7355-7359(1994)., PubMeb:8041794 DOI:10.1073/pnas.91.15.7355

  • "The status, quality, and expansion of the NIH full-length cDNAproject: the Mammalian Gene Collection (MGC).";,Genome Res. 14:2121-2127(2004).,PubMeb:15489334 DOI:10.1101/gr.2596504

  • "Identification of two mPPAR related receptors and evidence for theexistence of five subfamily members.";,Chen F., Law S.W., O'Malley B.W.;,Biochem. Biophys. Res. Commun. 196:671-677(1993)., PubMeb:8240342 DOI:10.1006/bbrc.1993.2302

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Protein Domain Databases | 3D Structure Database  | Sequence Annotation | Protein-protein Interaction Databases  | 
Binary Interactions | Enzyme and Pathway Databases |  Phylogenomic Database | Proteomics Database | 
Comparative Toxicogenomics Database | Order
Protein Domain Databases
InterPro

IPR003074, 1Cnucl_rcpt.

IPR003075, 1Cnucl_rcpt_B.

IPR008946, Nucl_hormone_rcpt_ligand-bd.

IPR000536, Nucl_hrmn_rcpt_lig-bd_core.

IPR001723, Str_hrmn_rcpt.

IPR001628, Znf_hrmn_rcpt.

IPR013088, Znf_NHR/GATA.
Gene3D

G3DSA:1.10.565.10, Nucl_hrmn_rcpt_lig_bd; 2.

G3DSA:3.30.50.10, Znf_NHR/GATA; 1.
PANTHER
Pfam

PF00104, Hormone_recep; 1.

PF00105, zf-C4; 1.
PRINTS

PR01288, PROXISOMEPAR.

PR01290, PROXISOMPABR.

PR00398, STRDHORMONER.

PR00047, STROIDFINGER.
SUPFAM

SSF48508, Str_ncl_receptor; 1.
PROSITE

PS00031, NUCLEAR_REC_DBD_1; 1.

PS51030, NUCLEAR_REC_DBD_2; 1.
3D Structure
Database (PDB)
Entry
Method
Resolution (A)
Chain
Positions
PDBsum
Sequence
Annotation
Feature key
Position(s)
Length
Description
Polypeptide chain 1 - 440 440 Peroxisome proliferator-activated /FTId=PRO_0000053487.
DNA-binding region 70 - 144 75 Nuclear receptor.
Zinc finger region 73 - 93 21 NR C4-type.
Zinc finger region 110 - 132 23 NR C4-type.
Region 253 - 440 188 Ligand-binding (Potential).
Different sources report differing sequences 149 - 150 2 EA -> DG (in Ref. 2; AAA19972).
Protein-protein
Interaction
Databases
DIP

DIP-29851N
IntAct

P35396
MINT
STRING

P35396
Binary Interactions
With
Entry
#Exp.
IntAct
PRKAA1 (xeno)Q13131 1EBI-1809541, EBI-1181405
PRKAA2 (xeno)P54646 1EBI-1809541, EBI-1383852
Enzyme and Pathway Databases
Pathway
Interaction DB
Reactome
Phylogenomic Database
HOVERGEN

HBG106004
InParanoid

P35396
OMA

SSLFLND
OrthoDB

EOG4FFD1Q
Proteomics
Database (PRIDE)

P35396
Comparative
Toxicogenomics
Database (CTD)

5467
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