19418

SEQUENCE   1189 AA;  135668 MW;  42E346B623F18E59 CRC64;
MQKSVRYNEG HALYLAMLAR KEGTKRGFLS KKAAEASRWH EKWFALYQNV LFYFEGEQSG
RPAGMYLLEG CSCERTPAPP RTNAGPAGAR DALDKQYYFT VLFGHDGQKP LELRCEEEQA
GKEWMEAIHQ ASYADILIER EVLMQKYIHL VQIVETEKIA TNQLRHQLED QDTEIERLKS
EIVALNKTKE RMRPYHVHQE EEDPDIKKIK KVQSFMRGWL CRRKWKTIVQ DYICSPHAES
MRKRNQIVFT MVEAETEYVH QLYILVNGFL RPLRMAASSK KPPINHDDVS SIFLNSETIM
FLHEIFHQGL KARLANWPTL VLADLFDILL PMLNIYQEFV RNHQYSLQVL ANCKQNRDFD
KLLKQYEANP ACEGRMLETF LTYPMFQIPR YIITLHELLA HTPHEHVERK SLEFAKSKLE
ELSRVMHDEV SDTENIRKNL AIERMIVEGC DILLDTSQTF IRQGSLIQVP SVERGKLSKV
RLGSLSLKKE GERQCFLFTK HFLICTRSSG GKLHLLKTGG VLSLIQCTLI EEPDGSDDDP
KGSGHMFGHL DFKIVVEPPD AASFTVVLLA PSRQEKAAWM SDISQCVDNI RCNGLMTIVF
EENSKVTVPH MIKSDARLHK DDTDICFSKT LNSCKVPQIR YASVERLLER LTDLRFLSID
FLNTFLHTYR IFTTATVVLA KLSDIYKRPF TSIPVRSLEL FFATSQNNRE HLVDGKSPRL
CRKFSSPPPL AVSRTSSPVR ARKLSLTSSL NSRIGALDLT NSSSSSSPTT TTHSPAASPP
PHTAVLESAP ADKAGDSADM SPCRSPTTPR HLRYRQPGGQ VADSAHCSVS PASAFAIATA
AAGHGSPPGF NNERTCDKEF IIRRTATNRV LNVLRHWVSK HAQDFELNNE LKMNVLNLLE
EVLRDPDLLP QERKATANIL RALSQDDQDD IHLKLEDIIQ MTDCPKAECF ETLSAMELAE
QITLLDHIVF RSIPYEEFLG QGWMKLDKNE RTPYIMKTSQ HFNEMSNLVA SQIMNYADIS
SRANAIEKWV AVADICRCLH NYNGVLEITS ALNRSAIYRL KKTWAKVSKQ TKALMDKLQK
TVSSEGRFKN LRETLKNCNP PAVPYLGMYL TDLAFIEEGT PNFTEEGLVN FSKMRMISHI
IREIRQFQQT AYRIDQQPKV IQYLLDKALV IDEDSLYELS LKIEPRLPA

• "Cloning and characterization of Ras-GRF2, a novel guanine nucleotideexchange factor for Ras.";,Fam N.P., Fan W.-T., Wang Z., Zhang L.-J., Chen H., Moran M.F.;,Mol. Cell. Biol. 17:1396-1406(1997)., PubMeb:9032266

• "The transcriptional landscape of the mammalian genome.";,Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,Hayashizaki Y.;,Science 309:1559-1563(2005).,PubMeb:16141072 DOI:10.1126/science.1112014

• "Ras binding triggers ubiquitination of the Ras exchange factor Ras-GRF2.";,de Hoog C.L., Koehler J.A., Goldstein M.D., Taylor P., Figeys D.,Moran M.F.;,Mol. Cell. Biol. 21:2107-2117(2001).,PubMeb:11238945 DOI:10.1128/MCB.21.6.2107-2117.2001

• "Targeted disruption of Ras-Grf2 shows its dispensability for mousegrowth and development.";,Fernandez-Medarde A., Esteban L.M., Nunez A., Porteros A.,Tessarollo L., Santos E.;,Mol. Cell. Biol. 22:2498-2504(2002)., PubMeb:11909944DOI:10.1128/MCB.22.8.2498-2504.2002

• "The exchange factor Ras-GRF2 activates Ras-dependent and Rac-dependent mitogen-activated protein kinase pathways.";,Fan W.-T., Koch C.A., de Hoog C.L., Fam N.P., Moran M.F.;,Curr. Biol. 8:935-938(1998).,PubMeb:9707409 DOI:10.1016/S0960-9822(07)00376-4

• "Ras-specific exchange factor GRF: oligomerization through its Dblhomology domain and calcium-dependent activation of Raf.";,Anborgh P.H., Qian X., Papageorge A.G., Vass W.C., DeClue J.E.,Lowy D.R.;,Mol. Cell. Biol. 19:4611-4622(1999)., PubMeb:10373510

• "Calmodulin-independent coordination of Ras and extracellular signal-regulated kinase activation by Ras-GRF2.";,de Hoog C.L., Fan W.-T., Goldstein M.D., Moran M.F., Koch C.A.;,Mol. Cell. Biol. 20:2727-2733(2000).,PubMeb:10733575 DOI:10.1128/MCB.20.8.2727-2733.2000

• "Prenylation of target GTPases contributes to signaling specificity ofRas-guanine nucleotide exchange factors.";,Gotoh T., Tian X., Feig L.A.;,J. Biol. Chem. 276:38029-38035(2001).,PubMeb:11500499 DOI:10.1074/jbc.M104658200

• "Dematin interacts with the Ras-guanine nucleotide exchange factorRas-GRF2 and modulates mitogen-activated protein kinase pathways.";,Lutchman M., Kim A.C., Cheng L., Whitehead I.P., Oh S.S., Hanspal M.,Boukharov A.A., Hanada T., Chishti A.H.;,Eur. J. Biochem. 269:638-649(2002).,PubMeb:11856323 DOI:10.1046/j.0014-2956.2001.02694.x

• "Developmentally regulated role for Ras-GRFs in coupling NMDAglutamate receptors to Ras, Erk and CREB.";,Tian X., Gotoh T., Tsuji K., Lo E.H., Huang S., Feig L.A.;,EMBO J. 23:1567-1575(2004).,PubMeb:15029245 DOI:10.1038/sj.emboj.7600151

• "p35/cyclin-dependent kinase 5 phosphorylation of ras guaninenucleotide releasing factor 2 (RasGRF2) mediates Rac-dependentextracellular signal-regulated kinase 1/2 activity, altering RasGRF2and microtubule-associated protein 1b distribution in neurons.";,Kesavapany S., Amin N., Zheng Y.-L., Nijhara R., Jaffe H., Sihag R.,Gutkind J.S., Takahashi S., Kulkarni A., Grant P., Pant H.C.;,J. Neurosci. 24:4421-4431(2004).,PubMeb:15128856 DOI:10.1523/JNEUROSCI.0690-04.2004

• "Activation of H-Ras in the endoplasmic reticulum by the RasGRF familyguanine nucleotide exchange factors.";,Arozarena I., Matallanas D., Berciano M.T., Sanz-Moreno V., Calvo F.,Munoz M.T., Egea G., Lafarga M., Crespo P.;,Mol. Cell. Biol. 24:1516-1530(2004).,PubMeb:14749369 DOI:10.1128/MCB.24.4.1516-1530.2004

• "The guanine nucleotide exchange factor RasGRF1 directly bindsmicrotubules via DHPH2-mediated interaction.";,Forlani G., Baldassa S., Lavagni P., Sturani E., Zippel R.;,FEBS J. 273:2127-2138(2006).,PubMeb:16649990 DOI:10.1111/j.1742-4658.2006.05226.x

• "Age-dependent participation of Ras-GRF proteins in coupling calcium-permeable AMPA glutamate receptors to Ras/Erk signaling in corticalneurons.";,Tian X., Feig L.A.;,J. Biol. Chem. 281:7578-7582(2006).,PubMeb:16407208 DOI:10.1074/jbc.M512060200

• "Distinct roles for Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) and Ras-GRF2 in the induction of long-term potentiation andlong-term depression.";,Li S., Tian X., Hartley D.M., Feig L.A.;,J. Neurosci. 26:1721-1729(2006).,PubMeb:16467520 DOI:10.1523/JNEUROSCI.3990-05.2006