Protein Annotations for hnRNP core protein A1, ROA1

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Name	Gene Symbol	Rec Full Name	Protein Information	Quick Quote	Price, Turnaround
ROA1_PANTR, Pan troglodytes (chimpanzee)	HNRNPA1	hnRNP core protein A1	Functions		Starting from $1600, 4 weeks
ROA1_PANTR, Pan troglodytes (chimpanzee)	HNRNPA1	hnRNP core protein A1	Protein Domains		Quote

Protein Names

Recommended name:	Heterogeneous nuclear ribonucleoprotein A1;
Alternative name(s):	Helix-destabilizing protein Single-strand-binding protein hnRNP core protein A1

Protein IDs
(Accession numbers)

UniProtKB

A5A6H4

NCBI RefSeq

NP_001091892.1, NM_001098422.2.

NP_001184040.1, NM_001197111.1.

XP_003318234.1, XM_003318186.1.

Organism

Latin Name/ (Common Name)	Pan troglodytes (Chimpanzee).
Taxonomic Identifier (NCBI)	9598

Gene Names

HNRNPA1 [GenPool]

GeneID

100615525

739306

747284

Genome
Annotation (Ensembl)

ENSPTRT00000009269, ENSPTRP00000008571; ENSPTRG00000005035

ENSPTRT00000010845, ENSPTRP00000048316; ENSPTRG00000028756

ENSPTRT00000060488, ENSPTRP00000055119; ENSPTRG00000031363

Protein Sequence

SEQUENCE   320 AA;  34196 MW;  59485C9FA1FF8AE1 CRC64;
MSKSESPKEP EQLRKLFIGG LSFETTDESL RSHFEQWGTL TDCVVMRDPN TKRSRGFGFV
TYATVEEVDA AMNARPHKVD GRVVEPKRAV SREDSQRPGA HLTVKKIFVG GIKEDTEEHH
LRDYFEQYGK IEVIEIMTDR GSGKKRGFAF VTFDDHDSVD KIVIQKYHTV NGHNCEVRKA
LSKQEMASAS SSQRGRSGSG NFGGGRGGGF GGNDNFGRGG NFSGRGGFGG SRGGGGYGGS
GDGYNGFGND GSNFGGGGSY NDFGNYNNQS SNFGPMKGGN FGGRSSGPYG GGGQYFAKPR
NQGGYGGSSS SSSYGSGRRF

General annotation

Function	Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection (By similarity).
Cofactor
Subunit structure	Identified in the spliceosome C complex. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with SEPT6 (By similarity).
Subcellular location	Nucleus (By similarity). Cytoplasm (By similarity). Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles continuously between the nucleus and the cytoplasm along with mRNA. Component of ribonucleosomes (By similarity).
Tissue specificity
Induction
Domain
Post-translational modification	Sumoylated (By similarity).
Involvement in disease

References

"Mapping of chimpanzee full-length cDNAs onto the human genome unveilslarge potential divergence of the transcriptome.";,Sakate R., Suto Y., Imanishi T., Tanoue T., Hida M., Hayasaka I.,Kusuda J., Gojobori T., Hashimoto K., Hirai M.;,Gene 399:1-10(2007).,PubMeb:17574350 DOI:10.1016/j.gene.2007.04.013
"DNA sequence and comparative analysis of chimpanzee chromosome 22.";,Watanabe H., Fujiyama A., Hattori M., Taylor T.D., Toyoda A.,Kuroki Y., Noguchi H., BenKahla A., Lehrach H., Sudbrak R., Kube M.,Taenzer S., Galgoczy P., Platzer M., Scharfe M., Nordsiek G.,Bloecker H., Hellmann I., Khaitovich P., Paeaebo S., Reinhardt R.,Zheng H.-J., Zhang X.-L., Zhu G.-F., Wang B.-F., Fu G., Ren S.-X.,Zhao G.-P., Chen Z., Lee Y.-S., Cheong J.-E., Choi S.-H., Wu K.-M.,Liu T.-T., Hsiao K.-J., Tsai S.-F., Kim C.-G., Oota S., Kitano T.,Kohara Y., Saitou N., Park H.-S., Wang S.-Y., Yaspo M.-L., Sakaki Y.;,Nature 429:382-388(2004).,PubMeb:15164055 DOI:10.1038/nature02564

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Protein Domain Databases

InterPro	IPR021662, HnRNPA1. IPR012677, Nucleotide-bd_a/b_plait. IPR000504, RRM_dom.
Gene3D	G3DSA:3.30.70.330, a_b_plait_nuc_bd; 1.
PANTHER
Pfam	PF11627, HnRNPA1; 1. PF00076, RRM_1; 2.
PRINTS
SUPFAM
PROSITE	PS50102, RRM; 2.

3D Structure
Database (PDB)

Entry

Method

Resolution (A)

Chain

Positions

PDBsum

Sequence
Annotation

Feature key	Position(s)	Length	Description
Initiator methionine	1	1	Removed (By similarity).
Polypeptide chain	2 - 320	319	Heterogeneous nuclear ribonucleoprotein /FTId=PRO_0000295287.
Domain	14 - 97	84	RRM 1.
Domain	105 - 184	80	RRM 2.
Region	4 - 94	91	Globular A domain.
Region	95 - 185	91	Globular B domain.
Region	218 - 240	23	RNA-binding RGG-box.
Region	268 - 305	38	Nuclear targeting sequence (By
Compositionally biased region	195 - 320	126	Gly-rich.
Compositionally biased region	308 - 313	6	Poly-Ser.
Posttranslational modification of a residue	2	1	N-acetylserine (By similarity).
Posttranslational modification of a residue	3	1	N6-acetyllysine (By similarity).
Posttranslational modification of a residue	4	1	Phosphoserine (By similarity).
Posttranslational modification of a residue	6	1	Phosphoserine (By similarity).
Posttranslational modification of a residue	91	1	Phosphoserine (By similarity).
Posttranslational modification of a residue	95	1	Phosphoserine (By similarity).
Posttranslational modification of a residue	113	1	N6-acetyllysine (By similarity).
Posttranslational modification of a residue	138	1	Phosphothreonine (By similarity).
Posttranslational modification of a residue	142	1	Phosphoserine (By similarity).
Posttranslational modification of a residue	167	1	Phosphotyrosine (By similarity).
Posttranslational modification of a residue	194	1	Omega-N-methylated arginine (By
Posttranslational modification of a residue	206	1	Dimethylated arginine; alternate (By
Posttranslational modification of a residue	206	1	Omega-N-methylarginine; alternate (By
Posttranslational modification of a residue	225	1	Dimethylated arginine; alternate (By
Posttranslational modification of a residue	225	1	Omega-N-methylarginine; alternate (By
Posttranslational modification of a residue	259	1	Phosphoserine (By similarity).
Posttranslational modification of a residue	286	1	Phosphoserine (By similarity).
Posttranslational modification of a residue	289	1	Phosphotyrosine (By similarity).
Posttranslational modification of a residue	295	1	Phosphotyrosine (By similarity).
Posttranslational modification of a residue	298	1	N6-acetyllysine (By similarity).
Posttranslational modification of a residue	305	1	Phosphotyrosine (By similarity).
Posttranslational modification of a residue	313	1	Phosphoserine (By similarity).
Posttranslational modification of a residue	316	1	Phosphoserine (By similarity).
Posttranslationally formed amino acid bonds	113	1	Glycyl lysine isopeptide (Lys-Gly)

Protein-protein
Interaction
Databases

DIP
IntAct
MINT
STRING

Binary Interactions

With

Entry

#Exp.

IntAct

Enzyme and Pathway Databases

Pathway Interaction DB
Reactome

Phylogenomic Database

HOVERGEN	HBG002295
InParanoid	A5A6H4
OMA
OrthoDB	EOG4HQDKF

Proteomics
Database (PRIDE)

Comparative
Toxicogenomics
Database (CTD)

144983

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