General annotation |
Function |
Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes. |
Cofactor |
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Subunit structure |
Interacts with ITGA1 and ITGB1 (Probable). Interacts with PLXNC1. |
Subcellular location |
Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Note=Detected in a punctate pattern on the cell membrane of basal and supra-basal skin keratinocytes. |
Tissue specificity |
Detected in skin keratinocytes and on endothelial cells from skin blood vessels (at protein level). Expressed in fibroblasts, keratinocytes, melanocytes, placenta, testis, ovary, spleen, brain, spinal chord, lung, heart, adrenal gland, lymph nodes, thymus, intestine and kidney. |
Induction |
Up-regulated in UV-irradiated fibroblasts, but not in UV-irradiated keratinocytes. |
Domain |
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Post-translational modification |
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Involvement in disease |
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References |
"New eukaryotic semaphorins with close homology to semaphorins of DNAviruses.";,Lange C., Liehr T., Goen M., Gebhart E., Fleckenstein B., Ensser A.;,Genomics 51:340-350(1998)., PubMeb:9721204 DOI:10.1006/geno.1998.5256
"Molecular cloning of a glycosylphosphatidylinositol-anchored moleculeCDw108.";,Yamada A., Kubo K., Takeshita T., Harashima N., Kawano K., Mine T.,Sagawa K., Sugamura K., Itoh K.;,J. Immunol. 162:4094-4100(1999)., PubMeb:10201933
"Human semaphorin K1 is glycosylphosphatidylinositol-linked anddefines a new subfamily of viral-related semaphorins.";,Xu X., Ng S., Wu Z.-L., Nguyen D., Homburger S., Seidel-Dugan C.,Ebens A., Luo Y.;,J. Biol. Chem. 273:22428-22434(1998)., PubMeb:9712866 DOI:10.1074/jbc.273.35.22428
"The molecular diversity of Sema7A, the semaphorin that carries theJMH blood group antigens.";,Seltsam A., Strigens S., Levene C., Yahalom V., Moulds M.,Moulds J.J., Hustinx H., Weisbach V., Figueroa D., Bade-Doeding C.,DeLuca D.S., Blasczyk R.;,Transfusion 47:133-146(2007).,PubMeb:17207242 DOI:10.1111/j.1537-2995.2007.01076.x
Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
"The status, quality, and expansion of the NIH full-length cDNAproject: the Mammalian Gene Collection (MGC).";,Genome Res. 14:2121-2127(2004).,PubMeb:15489334 DOI:10.1101/gr.2596504
"Characterization of the human leukocyte GPI-anchored glycoproteinCDw108 and its relation to other similar molecules.";,Angelisova P., Drbal K., Cerny J., Hilgert I., Horejsi V.;,Immunobiology 200:234-245(1999)., PubMeb:10416131
"Semaphorin 7A promotes axon outgrowth through integrins and MAPKs.";,Pasterkamp R.J., Peschon J.J., Spriggs M.K., Kolodkin A.L.;,Nature 424:398-405(2003).,PubMeb:12879062 DOI:10.1038/nature01790
"Semaphorin 7A initiates T-cell-mediated inflammatory responsesthrough alpha1beta1 integrin.";,Suzuki K., Okuno T., Yamamoto M., Pasterkamp R.J., Takegahara N.,Takamatsu H., Kitao T., Takagi J., Rennert P.D., Kolodkin A.L.,Kumanogoh A., Kikutani H.;,Nature 446:680-684(2007).,PubMeb:17377534 DOI:10.1038/nature05652
"Semaphorin 7a promotes spreading and dendricity in human melanocytesthrough beta1-integrins.";,Scott G.A., McClelland L.A., Fricke A.F.;,J. Invest. Dermatol. 128:151-161(2008).,PubMeb:17671519 DOI:10.1038/sj.jid.5700974
"Structural basis of semaphorin-plexin recognition and viral mimicryfrom Sema7A and A39R complexes with PlexinC1.";,Liu H., Juo Z.S., Shim A.H., Focia P.J., Chen X., Garcia K.C., He X.;,Cell 142:749-761(2010).,PubMeb:20727575 DOI:10.1016/j.cell.2010.07.040 |
