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Reviewed (UniProtKB/Swiss-Prot)

Note: Proteins listed in ProtBank™ database are NOT off-the-shelf [catalog] proteins. Customized protein production request can be made for any protein in this database by clicking on the corresponding button under "Quick Quote". Please ensure sequence accuracy and/or make any necessary modifications prior to submitting your quote request

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Reviewed (UniProtKB/Swiss-Prot)


Name Gene Symbol Rec Full Name Protein Information Quick Quote  Price,
Turnaround
SNRPA_BOVIN, Bos taurus (cattle) SNRPA U1 small nuclear ribonucleoprotein A Functions
wild_type
Starting from $1600,
4 weeks
Protein Domains
mutant
Quote

Protein Names | ProteinIDs  | Organism | Gene Names  | GeneID | Genome Annotation(Ensembl) |  Protein Sequence | 
General annotation |  References | Order
Protein Names
Recommended name:
 U1 small nuclear ribonucleoprotein A;
Alternative name(s):
Protein IDs
(Accession numbers)
UniProtKB
 Q2KIR1
NCBI RefSeq

NP_001039504.1, NM_001046039.1.
Organism
Latin Name/
(Common Name)
Bos taurus (Bovine).
Taxonomic Identifier (NCBI)
 9913
Gene Names
 SNRPA [GenPool]
GeneID

509802
Genome
Annotation (Ensembl)
Protein Sequence
 
SEQUENCE   282 AA;  31264 MW;  18B94F970C4BBEC5 CRC64;
MAVPETRPNH TIYINNLNEK IKKDELKKSL YAIFSQFGQI LDILVSRSLK MRGQAFVIFK
EVSSATNALR SMQGFPFYDK PMRIQYAKTD SDIIAKMKGT FVERDRKREK RKPKSQETPA
AKKAVQGGAA APVVGTVQGP VPGMPPMTQA PRIMHHMPGQ PPYMPPPGMI PPPGLAPGQL
PPGAMPPQQL MPGQMPPAQP LSENPPNHIL FLTNLPEETN ELMLSMLFNQ FPGFKEVRLV
PGRHDIAFVE FDNEVQAGAA RDALQGFKIT QNNAMKISFA KK
General annotation
Function
 Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP (By similarity). In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process (By similarity).
Cofactor
Subunit structure
 Belongs to the spliceosome where it is associated with snRNP U1. Interacts with SFPQ. Also component of a snRNP-free complex with SFPQ (By similarity).
Subcellular location

Nucleus (By similarity).
Tissue specificity
Induction
Domain
Post-translational modification

Involvement in disease

References

  • Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.

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Protein Domain Databases | 3D Structure Database  | Sequence Annotation | Protein-protein Interaction Databases  | 
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Protein Domain Databases
InterPro

IPR012677, Nucleotide-bd_a/b_plait.

IPR000504, RRM_dom.
Gene3D

G3DSA:3.30.70.330, a_b_plait_nuc_bd; 2.
PANTHER
Pfam

PF00076, RRM_1; 2.
PRINTS
SUPFAM
PROSITE

PS50102, RRM; 2.
3D Structure
Database (PDB)
Entry
Method
Resolution (A)
Chain
Positions
PDBsum
Sequence
Annotation
Feature key
Position(s)
Length
Description
Initiator methionine 1 1 Removed (By similarity).
Polypeptide chain 2 - 282 281 U1 small nuclear ribonucleoprotein A. /FTId=PRO_0000273977.
Domain 10 - 89 80 RRM 1.
Domain 208 - 282 75 RRM 2.
Compositionally biased region 140 - 206 67 Pro-rich.
Posttranslational modification of a residue 2 1 N-acetylalanine (By similarity).
Posttranslational modification of a residue 60 1 N6-acetyllysine (By similarity).
Protein-protein
Interaction
Databases
DIP
IntAct
MINT
STRING

Q2KIR1
Binary Interactions
With
Entry
#Exp.
IntAct
Enzyme and Pathway Databases
Pathway
Interaction DB
Reactome
Phylogenomic Database
HOVERGEN

HBG000895
InParanoid

Q2KIR1
OMA
OrthoDB

EOG498V1W
Proteomics
Database (PRIDE)

Q2KIR1
Comparative
Toxicogenomics
Database (CTD)

6626
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Phone: 1-877-436-7274 (Toll-Free) 1-732-885-9188
Fax: 1-732-210-0262