Protein Annotations for Xylosyltransferase II, XYLT2

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Name	Gene Symbol	Rec Full Name	Protein Information	Quick Quote	Price, Turnaround
XYLT2_HUMAN, Homo sapiens (human)	XYLT2	Xylosyltransferase II	Functions		Quote
XYLT2_HUMAN, Homo sapiens (human)	XYLT2	Xylosyltransferase II	Protein Domains		Quote

Protein Names

Recommended name:	Xylosyltransferase 2;
Alternative name(s):	Peptide O-xylosyltransferase 1 Xylosyltransferase II

Protein IDs
(Accession numbers)

UniProtKB	Q9H1B5
NCBI RefSeq	NP_071450.2, NM_022167.2.

Organism

Latin Name/ (Common Name)	Homo sapiens (Human).
Taxonomic Identifier (NCBI)	9606

Gene Names

XYLT2 [GenPool]

GeneID

64132

Genome
Annotation (Ensembl)

ENST00000017003, ENSP00000017003; ENSG00000015532

Protein Sequence

SEQUENCE   865 AA;  96767 MW;  EF477B7C3C1B964B CRC64;
MVASARVQKL VRRYKLAIAT ALAILLLQGL VVWSFSGLEE DEAGEKGRQR KPRPLDPGEG
SKDTDSSAGR RGSTGRRHGR WRGRAESPGV PVAKVVRAVT SRQRASRRVP PAPPPEAPGR
QNLSGAAAGE ALVGAAGFPP HGDTGSVEGA PQPTDNGFTP KCEIVGKDAL SALARASTKQ
CQQEIANVVC LHQAGSLMPK AVPRHCQLTG KMSPGIQWDE SQAQQPMDGP PVRIAYMLVV
HGRAIRQLKR LLKAVYHEQH FFYIHVDKRS DYLHREVVEL AQGYDNVRVT PWRMVTIWGG
ASLLRMYLRS MRDLLEVPGW AWDFFINLSA TDYPTRTNEE LVAFLSKNRD KNFLKSHGRD
NSRFIKKQGL DRLFHECDSH MWRLGERQIP AGIVVDGGSD WFVLTRSFVE YVVYTDDPLV
AQLRQFYTYT LLPAESFFHT VLENSLACET LVDNNLRVTN WNRKLGCKCQ YKHIVDWCGC
SPNDFKPQDF LRLQQVSRPT FFARKFESTV NQEVLEILDF HLYGSYPPGT PALKAYWENT
YDAADGPSGL SDVMLTAYTA FARLSLHHAA TAAPPMGTPL CRFEPRGLPS SVHLYFYDDH
FQGYLVTQAV QPSAQGPAET LEMWLMPQGS LKLLGRSDQA SRLQSLEVGT DWDPKERLFR
NFGGLLGPLD EPVAVQRWAR GPNLTATVVW IDPTYVVATS YDITVDTETE VTQYKPPLSR
PLRPGPWTVR LLQFWEPLGE TRFLVLPLTF NRKLPLRKDD ASWLHAGPPH NEYMEQSFQG
LSSILNLPQP ELAEEAAQRH TQLTGPALEA WTDRELSSFW SVAGLCAIGP SPCPSLEPCR
LTSWSSLSPD PKSELGPVKA DGRLR

General annotation

Function	Probably catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes (By similarity). Its enzyme activity has not been demonstrated.
Cofactor	Divalent cations (By similarity).
Subunit structure	Monomer (By similarity).
Subcellular location	Endoplasmic reticulum membrane; Single-pass type II membrane protein (By similarity). Golgi apparatus membrane; Single-pass type II membrane protein (By similarity).
Tissue specificity	Widely expressed. Expressed at higher level in kidney and pancreas.
Induction
Domain
Post-translational modification	Contains disulfide bonds (By similarity).
Involvement in disease

References

"Molecular cloning and expression of human UDP-D-xylose:proteoglycancore protein beta-D-xylosyltransferase and its first isoform XT-II.";,Goetting C., Kuhn J., Zahn R., Brinkmann T., Kleesiek K.;,J. Mol. Biol. 304:517-528(2000)., PubMeb:11099377 DOI:10.1006/jmbi.2000.4261
"The secreted protein discovery initiative (SPDI), a large-scaleeffort to identify novel human secreted and transmembrane proteins: abioinformatics assessment.";,Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,Wood W.I., Godowski P.J., Gray A.M.;,Genome Res. 13:2265-2270(2003)., PubMeb:12975309 DOI:10.1101/gr.1293003
"The status, quality, and expansion of the NIH full-length cDNAproject: the Mammalian Gene Collection (MGC).";,Genome Res. 14:2121-2127(2004).,PubMeb:15489334 DOI:10.1101/gr.2596504

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Protein Domain Databases

InterPro	IPR003406, Glyco_trans_14.
Gene3D
PANTHER
Pfam	PF02485, Branch; 1.
PRINTS
SUPFAM
PROSITE

3D Structure
Database (PDB)

Entry

Method

Resolution (A)

Chain

Positions

PDBsum

Sequence
Annotation

Feature key	Position(s)	Length	Description
Polypeptide chain	1 - 865	865	Xylosyltransferase 2. /FTId=PRO_0000191406.
Topological domain	1 - 15	15	Cytoplasmic (Potential).
Topological domain	37 - 865	829	Lumenal (Potential).
Transmembrane region	16 - 36	21	Helical; Signal-anchor for type II
Glycosylation site	122	1	N-linked (GlcNAc...) (Potential).
Glycosylation site	327	1	N-linked (GlcNAc...) (Potential).
Glycosylation site	683	1	N-linked (GlcNAc...) (Potential).
Natural variance	583 - 638	56	FEPRGLPSSVHLYFYDDHFQGYLVTQAVQPSAQGPAETLEM /FTId=VSP_013758.
Natural variance	639 - 865	227	Missing (in isoform 2). /FTId=VSP_013759.
Natural variance	60	1	G -> R (in dbSNP:rs739990). /FTId=VAR_049328.
Natural variance	305	1	R -> T (in dbSNP:rs12451299). /FTId=VAR_022453.
Natural variance	801	1	T -> R (in dbSNP:rs6504649). /FTId=VAR_022454.

Protein-protein
Interaction
Databases

DIP
IntAct
MINT
STRING	Q9H1B5

Binary Interactions

With

Entry

#Exp.

IntAct

Enzyme and Pathway Databases

Pathway Interaction DB
Reactome

Phylogenomic Database

HOVERGEN	HBG059443
InParanoid	Q9H1B5
OMA	DYPTRTN
OrthoDB	EOG4RR6GN

Proteomics
Database (PRIDE)

Q9H1B5

Comparative
Toxicogenomics
Database (CTD)

64132

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