A small North American biotech company was founded by scientists whose goal is to engineer novel biologic drugs, such as antibodies and growth factors for oncology and immunology, enzyme replacement therapies for genetic disorders, and myriad other therapeutic proteins. The company's expertise is in computational modeling of protein dynamics to design new or improved enzymes. Their virtual simulations allow them to predict which mutations will enhance protein stability, substrate affinity, enzymatic activity, or other key features that contribute to drug efficacy.
To validate their in silico mutagenesis, they need to synthesize the mutated sequences, express the proteins for biochemical characterization, and perform cell-based functional assays. Promising candidates can then be licensed to pharmaceutical companies that have the infrastructure to follow through with pre-clinical, potentially bringing new drugs to patients in need. Gene synthesis allows high-throughput, fast, accurate construction of mutant sequences that are then cloned into expression vectors. Gene synthesis also facilitates high-level protein expression through host cell-specific codon optimization, allowing rapid purification of sufficient quantities of protein for biochemical characterization.
By outsourcing to GenScript, the industry leader in capacity and total automation of gene synthesis, this biotech client was able to speed up their R&D process, meet the deadlines from their pharmaceutical partners, and secure more funding from venture capital investors.
To validate their in silico mutagenesis, they need to synthesize the mutated sequences, express the proteins for biochemical characterization, and perform cell-based functional assays. Promising candidates can then be licensed to pharmaceutical companies that have the infrastructure to follow through with pre-clinical, potentially bringing new drugs to patients in need. Gene synthesis allows high-throughput, fast, accurate construction of mutant sequences that are then cloned into expression vectors. Gene synthesis also facilitates high-level protein expression through host cell-specific codon optimization, allowing rapid purification of sufficient quantities of protein for biochemical characterization.
By outsourcing to GenScript, the industry leader in capacity and total automation of gene synthesis, this biotech client was able to speed up their R&D process, meet the deadlines from their pharmaceutical partners, and secure more funding from venture capital investors.
