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Catalog Products » Recombinant Proteins » Catalog Proteins - View by Cat. No. » BAFF Receptor (BAFF-R), Human

BAFF-R, Human

Synonyms BAFF Receptor ( BAFF-R), Human;
Description BAFF Receptor (BAFF-R), a member of the TNFR superfamily, is highly expressed in spleen, lymph node, and resting B cells and to some extent in activated B cells, resting CD4+ cells and peripheral blood leukocytes. BAFF-R is a type III transmembrane protein that binds with high specificity to BAFF (TNFSF13B). BAFF-R/BAFF signaling plays a critical role in B cell survival and maturation.
Species Human
Source E. coli
Biological Activity Fully biologically active when compared to standard. The ED50 as determined by its ability to block BAFF induced mouse splenocyte survival is 1.0-5.0 μg/ml in the presence of 1.0 μg/ml of rHuBAFF.
Sequence
MRRGPRSLRG RDAPAPTPCV PAECFDLLVR HCVACGLLRT
PRPKPAGASS PAPRTALQPQ ESVGAGAGEA ALPLPG

Measured Molecular Weight Approximately 7.8 kDa, a single non-glycosylated polypeptide chain containing 76 amino acids.
Purity > 95 % by reduced SDS-PAGE analyses.
Formulation Lyophilized from a 0.2 μm filtered concentrated solution in 20 mM PB, pH 8.0, 500 mM NaCl.
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
Endotoxin Level Less than 1 EU/μg of rHuBAFF-R as determined by LAL method.
Physical Appearance Sterile Filtered White lyophilized (freeze-dried) powder.
Usage This material is for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE.
Storage This lyophilized preparation is stable at 2-8 °C, but should be kept at -20 °C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 °C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 °C to -70 °C. Avoid repeated freeze/thaw cycles.
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Cat. No. Z02725
Size
Price
50 ug $159.00
1 mg $1049.00
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