|Description||Exendin-4 is a novel 39-amino acid peptide isolated from the venom of the Gila monster Heloderma suspectum. It shares 53% sequence homology with GLP-17-36amide and interacts with the same membrane receptor. Exendin-4 enhances glucose-dependent insulin secretion, suppresses inappropriately elevated glucagon secretion, and slows gastric emptying in vivo. It also promotes ÃŸ-cell proliferation and neogenesis in vitro and in animal models. Recombinant Exendin-4 is E. coli expression of a synthetic DNA squence encoding the 39 amino acid of Exendin-4.|
|Biological Activity||1. Regulates Glucose levels rapidly
2. Reduces Insulin resistence
3. Reduces Glucagon
4. Reduces HbA1c
5. Stimulates beta cell growth which stimulates insulin production.
|Measured Molecular Weight||Approximately 4.2 kDa, a single non-glycosylated polypeptide chain containing 39 amino acids.|
|Purity||>96% by SDS-PAGE and HPLC analyses.|
|Formulation||Lyophilized from a 0.2 μm filtered solution in PBS, pH 7.4.|
|Reconstitution||We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20 °C. Further dilutions should be made in appropriate buffered solutions.|
|Endotoxin Level||Less than 0.2EU/ug of rExendin-4 as determined by LAL method.|
|Physical Appearance||Sterile Filtered White lyophilized (freeze-dried) powder.|
|Usage||This material is for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE.|
|Storage||This lyophilized preparation is stable at 2-8 °C, but should be kept at -20 °C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 °C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 °C to -70 °C. Avoid repeated freeze/thaw cycles.|
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