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Catalog Products » Recombinant Proteins » Growth Factors » Fibrobalst Growth Factor-18 (FGF-18), Human

FGF-18, Human

Synonyms zFGF5, FGFI
Description Fibroblast growth factor 18 (FGF18) is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine.
Species Human
Source E. coli
Biological Activity Fully biologically active when compared to standard. The ED50 as determined by thymidine uptake assay using FGF-receptors transfected BaF3 cells is less than 0.5 ng/ml, corresponding to a specific activity of > 2.0 × 106 IU/mg.
Sequence
AEENVDFRIH VENQTRARDD VSRKQLRLYQ LYSRTSGKHI
QVLGRRISAR GEDGDKYAQL LVETDTFGSQ VRIKGKETEF
YLCMNRKGKL VGKPDGTSKE CVFIEKVLEN NYTALMSAKY
SGWYVGFTKK GRPRKGPKTR ENQQDVHFMK RYPKGQPELQ
KPFKYTTVTK RSRRIRPTHP A

Measured Molecular Weight Approximately 21.1 kDa, a single non-glycosylated polypeptide chain containing 181 amino acids.
Purity > 95 % by SDS-PAGE and HPLC analyses.
Formulation Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4.
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
Endotoxin Level Less than 1 EU/μg of rHuFGF-18 as determined by LAL method.
Physical Appearance Sterile Filtered White lyophilized (freeze-dried) powder.
Storage This lyophilized preparation is stable at 2-8 °C, but should be kept at -20 °C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 °C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 °C to -70 °C. Avoid repeated freeze/thaw cycles.


Cat. No.
Product Name
Price
Z03011-1
FGF-18, Human - 1 mg
$1500.00
 


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Cat. No. Z02937
Size
Price
5 ug $65.00