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Catalog Products » Recombinant Proteins » Cytokines » Interferon-gamma (IFN-γ), Human(CHO-expressed)

IFN-γ, Human(CHO-expressed)

Synonyms Immune Interferon, type II interferon, T cell interferon, MAF
Description Human Interferon gamma (hIFN-γ) is amacrophage-activating factor and the lone member of Interferon type II. The active form of IFN-γ is an antiparallel dimer that interacts with the receptor IFN-γR1 and sets off IFN-γ/JAK/STAT pathway. IFN-γ signaling does diverse biological functions primarily related to host defense and immune regulation, including antiviral and antibacterial defense, apoptosis, inflammation, and innate and acquired immunity. While IFN-γ–induced inflammatory cascade summons a variety of immune-related cell types, such as macrophages, natural killer (NK) cells and cytotoxic T lymphocytes (CTLs), IFN-γ is also implicated in resistance to NK cell and CTL responses and in immune escape in a variety of cancers.
Species Human
Source CHO
Biological Activity ED50 < 2 ng/ml, measured in a cytotoxicity assay using HT-29 cells, corresponding to a specific activity of > 5×105 units/mg.
Sequence
QDPYVKEAEN LKKYFNAGHS DVADNGTLFL GILKNWKEES
DRKIMQSQIV SFYFKLFKNF KDDQSIQKSV ETIKEDMNVK
FFNSNKKKRD DFEKLTNYSV TDLNVQRKAI HELIQVMAEL
SPAAKTGKRK RSQMLFRGRR ASQ

Measured Molecular Weight 15-25 kDa, observed by non-reducing SDS-PAGE.
Purity > 95% as analyzed by SDS-PAGE and HPLC.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O or PBS at 100 μg/ml.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant Human Interferon gamma (IFN-γ) remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, rh IFN-γ should be stable up to 1 week at 4°C or up to 2 months at -20°C.
Note For research use only

  • IFN-γ, Human(CHO-expressed)
  • IFN-γ, Human(CHO-expressed)

    ED₅₀< 2 ng/ml, measured in a cytotoxicity assay using HT-29 cells, corresponding to a specific activity of > 5×10⁵ units/mg.




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Cat. No. Z02986
Size
Price
50 ug $60.00
10 ug $25.00
1 mg $425.00