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Catalog Products » Recombinant Proteins » Growth Factors » Macrophage Colony Stimulating Factor (M-CSF), Rat

M-CSF, Rat

Synonyms Macrophage Colony Stimulating Factor, MGI-IM,CSF1, CSF-1, MCSF
Description Macrophage-Colony Stimulating Factor (M-CSF), also known as Colony Stimulating Factor-1 (CSF-1), can stimulate the survival, proliferation and differentiation of mononuclear phagocytes, in addition to the spreading and motility of macrophages[1]. M-CSF is mainly produced by monocytes, macrophages, fibroblasts, and endothelial cells [2]. M-CSF interaction with its receptor, c-fms, has been implicated in the growth, invasion, and metastasis of of several diseases, including breast and endometrial cancers [1][3][4].
Accession No NP_076471.3
Species Rat
Source CHO
Biological Activity ED50 < 2.5 ng/ml, measured in a cell proliferation assay using Murine M-NFS-60 cells, corresponding to a specific activity of > 4×105 units/mg.
Sequence
EVSEHCSHMI GNGHLQILQQ LIDSQMETAC LIEYKFVDQE
QLDDPVCYLK KAFVLVQVII EETMRFKDNT PNANATERLQ
ELSMKLNSCF IKDYKEQNEA CVQTYKESPL RLLEKIKNFF
NETKNFLEKD WNIFSKNCND SLAKCSSRDV VTKP

Measured Molecular Weight 32-40 kDa, observed by non-reducing SDS-PAGE.
Purity > 95% as analyzed by SDS-PAGE.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O or PBS at 100 μg/ml.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant Rat Macrophage-Colony Stimulating Factor (M-CSF) remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, rrM-CSF should be stable up to 1 week at 4°C or up to 2 months at -20°C.
Note For research use only


3. Jani R. Jensen et al. (2010), Fertil Steril. 93(1): 251.

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Cat. No. Z03010
Size
Price
5 ug $65.00
25 ug $159.00