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Catalog Products » Recombinant Proteins » Growth Factors » Fibroblast Growth Factor-18 (FGF-18), Human

FGF-18, Human

Synonyms Fibroblast Growth Factor-18, zFGF5, FGFI
Description Fibroblast Growth Factor-18 (FGF-18) is a heparin-binding growth factor that is a member of the FGF family. FGF-18 signals through FGFR 1c, 2c, 3c, and 4. FGF-18 plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. FGF-18 is required for normal ossification and bone development. It can also stimulate hepatic and intestinal proliferation.
Recombinant human Fibroblast Growth Factor-18 (rhFGF-18) produced in E. coli is a single non-glycosylated polypeptide chain containing 174 amino acids. A fully biologically active molecule, rhFGF-18 has a molecular mass of 20.3 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.
Species Human
Source E. coli
Biological Activity ED50 < 10 ng/ml, measured by a cell proliferation assay using 3T3 Cells, corresponding to a specific activity of > 1.0× 105units/mg.
Sequence
MAEENVDFRI HVENQTRARD DVSRKQLRLY QLYSRTSGKH
IQVLGRRISA RGEDGDKYAQ LLVETDTFGS QVRIKGKETE
FYLCMNRKGK LVGKPDGTSK ECVFIEKVLE NNYTALMSAK
YSGWYVGFTK KGRPRKGPKT RENQQDVHFM KRYPKGQPEL
QKPFKYTTVT KRSR

Measured Molecular Weight 20.3 kDa, observed by reducing SDS-PAGE.
Purity > 95% by SDS-PAGE and HPLC analyses.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O at 100 μg/ml.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant human Fibroblast Growth Factor-18 (rhFGF-18) remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, rhFGF-18 should be stable up to 2 weeks at 4°C or up to 3 months at -20°C.
Note For research use only




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Cat. No. Z03011
Size
Price
10 ug $65.00
50 ug $159.00
1 mg $1500.00