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Catalog Products » Recombinant Proteins » Cytokines » Interleukin-10 (IL-10), Rat

IL-10, Rat

Synonyms Cytokine synthesis inhibitory factor; CSIF; TGIF; IL10A
Description Interleukin-10 (IL-10), also known as cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine produced by a variety of cell lines including T-cells, macrophages and mast cells. IL-10 is classified as a class-2 cytokine, a set of cytokines including IL-19, IL-20, IL-22, IL-24, and IL-26. IL-10 can inhibit the synthesis of pro-inflammatory cytokines such as IFN-gamma, IL-2, IL-3, TNF and GM-CSF. It also stimulates Th2 responses, but suppresses the antigen-presentation capacity of antigen presenting cells.

Recombinant rat Interleukin-10 (IL-10)produced in E. coli is a single non-glycosylated polypeptide chain containing 161 amino acids. A fully biologically active molecule, recombinant rat Interleukin-10 (IL-10) has a molecular mass of 18.7kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.
Accession No P29456
Species Rat
Source E. coli
Biological Activity ED50 < 0.5μg/ml, measured by a cell proliferation assay using C6 cells, corresponding to a specific activity of > 2.0× 103 units/mg.
Sequence
MSKGHSIKGD NNCTHFPVSQ THMLRELRAA FSQVKTFFQK
KDQLDNIVLT DSLLQDFKGY LGCQALSEMI KFYLVEVMPQ
AENHGPEIKE HLNSLGEKLK TLWIQLRRCH RFLPCENKSK
AVEQVKNDFN KLQDKGVYKA MNEFDIFINC IEAYVTLKMK
N

Measured Molecular Weight 18.7 kDa, observed by reducing SDS-PAGE.
Purity > 95% by SDS-PAGE and HPLC analyses.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O at 100 μg/ml.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant rat Interleukin-10 (IL-10) remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, IL-10 should be stable up to 2 weeks at 4°C or up to 3 months at -20°C.


Cat. No.
Product Name
Price
Z02707-10
IL-10, Human - 10 ug
$159.00
Z03121-10
IL-10, Human(CHO-expressed) - 10 ug
$85.00
Z02036-1
IL-10, Mouse - 1 mg
$3600.00
Z03161-10
IL-10, Mouse(CHO-expressed) - 10 ug
$85.00
Z03171-10
IL-10, Rat (CHO-expressed) - 10 ug
$85.00
 


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Cat. No. Z03018
Size
Price
50 ug $275.00
10 ug $85.00
1 mg $2100.00