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Catalog Products » Recombinant Proteins » Cytokines » Interleukin-11 (IL-11), Mouse(HEK 293-expressed)

IL-11, Mouse(HEK 293-expressed)

Synonyms IL-11
Description Interleukin-11 (IL-11) is a pleiotropic cytokine that was originally detected in the conditioned medium of an IL-1α-stimulated primate bone marrow stromal cell line (PU-34) as a mitogen for the IL-6-responsive mouse plasmacytoma cell line T11. IL-11 contains no cysteine residues or potential glycosylation sites. IL-11 has multiple effects on both hematopoietic and nonhematopoietic cells. Many of the biological effects described for IL-11 overlap those for IL-6. In vitro, IL-11 can synergize with IL-3, IL-4 and SCF to shorten the G0 period of early hematopoietic progenitors. IL-11 also enhances the IL-3-dependent megakaryocyte colony formation. IL-11 has been found to stimulate the T cell dependent development of specific immunoglobulin-secreting B cell.
Accession No P47873
Species Mouse
Source HEK 293
Specific Activity ED50 < 3 ng/ml, measured in a cell proliferation assay using T11 cells.
Sequence
GPPAGSPRVS SDPRADLDSA VLLTRSLLAD TRQLAAQMRD
KFPADGDHSL DSLPTLAMSA GTLGSLQLPG VLTRLRVDLM
SYLRHVQWLR RAGGPSLKTL EPELGALQAR LERLLRRLQL
LMSRLALPQA APDQPVIPLG PPASAWGSIR AAHAILGGLH
LTLDWAVRGL LLLKTRL

Measured Molecular Weight ~21 kDa, observed by reducing SDS-PAGE.
Purity > 95% as analyzed by SDS-PAGE and HPLC.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O or PBS at 100 μg/ml.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant Mouse Interleukin-11 (IL-11) remains stable up to 6 months when stored at lower than -70°C from date of receipt. Upon reconstitution, Mouse Interleukin-11 (IL-11) should be stable up to 1 week at 4°C or up to 2 months at -20°C.
Note For research use only




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Cat. No. Z03052
Size
Price
50 ug $275.00
10 ug $85.00
1 mg $2100.00
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