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Catalog Products » Recombinant Proteins » Cytokines » Interleukin-11 (IL-11), Human(CHO-expressed)

IL-11, Human(CHO-expressed)

Synonyms AGIF (Adipogenesis inhibitory factor)
Description Interleukin-11 is a pleiotropic cytokine that was originally detected in the conditioned medium of an IL-1α-stimulated primate bone marrow stromal cell line (PU-34) as a mitogen for the IL-6-responsive mouse plasmacytoma cell line T11. IL-11 has multiple effects on both hematopoietic and non-hematopoietic cells. Many of the biological effects described for IL-11 overlap with those for IL-6. In vitro, IL-11 can synergize with IL-3, IL-4 and SCF to shorten the G0 period of early hematopoietic progenitors. IL-11 also enhances the IL-3-dependent megakaryocyte colony formation. IL-11 has been found to stimulate the T cell-dependent development of specific immunoglobulin-secreting B cells.
Accession No P20809.1
Species Human
Source CHO
Specific Activity ED50 <5 ng/ml, measured in a proliferation assay using T11 cells.
Sequence
PGPPPGPPRV SPDPRAELDS TVLLTRSLLA DTRQLAAQLR
DKFPADGDHN LDSLPTLAMS AGALGALQLP GVLTRLRADL
LSYLRHVQWL RRAGGSSLKT LEPELGTLQA RLDRLLRRLQ
LLMSRLALPQ PPPDPPAPPL APPSSAWGGI RAAHAILGGL
HLTLDWAVRG LLLLKTRL

Measured Molecular Weight ~23 kDa, observed by reducing SDS-PAGE.
Purity > 95% as analyzed by SDS-PAGE and HPLC.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O or PBS at 100 μg/ml.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant Human Interleukin-11 remains stable up to 6 months when stored at lower than -70°C from date of receipt. Upon reconstitution, Human Interleukin-11 should be stable up to 1 week at 4°C or up to 2 months at -20°C.
Note For research use only




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Cat. No. Z03108
Size
Price
5 ug $85.00
25 ug $275.00
1 mg $2900.00
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