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Catalog Products » Recombinant Proteins » Chemokines » HCC‑4/CCL16, Human(CHO-expressed)

HCC‑4/CCL16, Human(CHO-expressed)

Synonyms HCC‑4/CCL16, Human
Description Human HCC­4, also named NCC­4and Chemokine (C-C motif) ligand 16 (CCL16) is a small cytokine belonging to the CC chemokine family that is known under several pseudonyms, including Liver-expressed chemokine (LEC) and Monotactin-1 (MTN-1). It can signal through the CCR8 and CCR1 receptors, and it is chemotactic towards monocytes and lymphocytes but not neutrophils. HCC-4 is expressed weakly by some lymphocytes, including NK cells, T cells, and some T cell clones. The expression of HCC-4 in monocytes is greatly up-regulated in the presence of IL-10. HCC-4 induces a calcium flux in thp-1 cells that are desensitized prior to the expression of RANTES.
Recombinant human HCC‑4/CCL16 produced in CHO cells is a single non-glycosylated polypeptide chain containing 97 amino acids. A fully biologically active molecule, rhHCC‑4/CCL16has a molecular mass of 12 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.
Accession No O15467
Species Human
Source CHO
Biological Activity The EC50 value of human HCC‑4/CCL16 on Ca2+ mobilization assay in CHO-K1/Ga15/hCCR1 cells (human Ga15 and human CCR1 stably expressed in CHO-K1 cells) is less than 1.5 μg/ml.

Measured Molecular Weight 12 kDa, observed by reducing SDS-PAGE.
Purity > 98% as analyzed by SDS-PAGE.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O or PBS at 100 μg/ml.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant human HCC‑4/CCL16 remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, human HCC‑4/CCL16 should be stable up to 1 week at 4°C or up to 2 months at -20°C.
Note For research use only

Cat. No. Product Name Quantity Price
HCC-4/CCL16, Human - 20 ug

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Cat. No. Z03236
Size Price
10 ug $59.00
50 ug $159.00
1 mg $1100.00