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Home » Gene Synthesis & Molecular Biology Services » B7-H2/ICOSLG Fc Chimera, Human

B7-H2/ICOSLG Fc Chimera, Human

Synonyms ICOSLG; B7-H2; B7H2; B7RP-1; B7RP1; CD275; GL50; ICOS-L; ICOSL; LICOS; ICOS ligand
Description B7-H2, best known as the ligand of inducible co-stimulator, belongs to B7-CD28 family. B7-H2 is a transmembrane glycoprotein of approximately 60 kDa and is expressed on antigen presenting cells such as B cells, macrophages, dendritic cells, and also in monocytes. It’s a ligand for CD28 and CTLA-4 in human, whereas these interactions are not conserved in mouse. B7-H2 and B7-1 or B7-2 interacts with CD28 through distinctive domains. B7-H2-CD28 interaction is essential for the co-stimulation of human T cells' primary responses to allogeneic antigens and memory recall responses.
Recombinant Human B7-H2 Fc Chimera produced in HEK293 cells. It’s a polypeptide chain containing 473 amino acids with the C-termimal human IgG1 Fc fragment. A fully biologically active molecule, rhB7-H2 has a molecular mass of 70-80 kDa, analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.
Accession No O75144
Species Human
Source HEK293
Biological Activity Immobilized ICOS Fc Chimera, Human(Cat:Z03412) at 5 μg/mL (100 μL/well) can bind Biotin-B7-H2/ICOSLG Fc Chimera, Human with a linear range of 0.76-12.21ng/mL when detected by Streptavidin-HRP second antibody..
Sequence
DTQEKEVR AMVGSDVE LSCACPEG SRFDLNDV YVYWQTSE
SKTVVTYH IPQNSSLE NVDSRYRN RALMSPAG MLRGDFSL
RLFNVTPQ DEQKFHCL VLSQSLGF QEVLSVEV TLHVAANF
SVPVVSAP HSPSQDEL TFTCTSIN GYPRPNVY WINKTDNS
LLDQALQN DTVFLNMR GLYDVVSV LRIARTPS VNIGCCIE
NVLLQQNL TVGSQTGN DIGERDKI TENPVSTG EKNAATWS

Measured Molecular Weight 70-80 kDa, observed by reducing SDS-PAGE.
Purity > 97% as analyzed by reducing SDS-PAGE.
Formulation Lyophilized from a 0.2 μm filtered solution in PBS, 5% trehalose and mannitol.
Reconstitution Reconstituted in ddH2O at 100 μg/mL.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant B7-H2 Fc Chimera, Human remains stable for up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, Human B7-H2 Fc should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.
Note For research use only

  • B7-H2/ICOSLG Fc Chimera, Human
  • B7-H2/ICOSLG Fc Chimera, Human

    Immobilized ICOS Fc Chimera, Human(Cat:Z03412) at 5 μg/mL (100 μL/well) can bind Biotin-B7-H2/ICOSLG Fc Chimera, Human with a linear range of 0.76-12.21ng/mL.


Cat. No.
Product Name
Price
Z03409-50
B7-1(CD80) Fc Chimera, Human - 50 ug
$159.00
Z03416-1
B7-2/CD86 Fc Chimera, Human - 1 mg
$1200.00
Z03452-1
B7-2/CD86 Fc His, Human - 1 mg
$1200.00
Z03415-1
B7-H2/ICOSLG His, Human - 1 mg
$1200.00
Z03426-100
B7-H3 Fc Chimera, Human - 100 ug
$275.00
Z03427-100
B7-H3, His, Human - 100 ug
$395.00
 


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Cat. No. Z03414
Size
Price
100 μg $250.00
1 mg $1200.00