Catalog Products » SARS-CoV-2 Spike protein (S1, K417N, His Tag)

SARS-CoV-2 Spike protein (S1, K417N, His Tag)

*This product has been discontinued!*
SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) also known as 2019-nCoV (2019 Novel Coronavirus) is a virus that causes illnesses ranging from the common cold to severe diseases. SARS-CoV-2 Spike Protein is composed of S1 domain and S2 domain.K417N/T mutation located on the tip of the spike protein, an area important to the antibody recognition process. In some experiments the K417N/T mutation has been associated with decreased antibody recognition and possible resistance to some antibodies. The possibility of a more effective virus/cell binding process has also been described.
Z03530
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Product Introduction
Species SARS-CoV-2
Protein Construction
S1 protein [Gln14-Arg685 (K417N)]
Accession # P0DTC2		 Poly-His
N-term C-term
Purity > 90% as analyzed by SDS-PAGE
Endotoxin Level < 0.2 EU/μg of protein by gel clotting method
Biological Activity SARS-CoV-2 Spike protein (S1, K417N, His Tag) can bind with human ACE2 (Cat. No.: Z03484) in functional ELISA assay.
Expression System 293 Cells
Theoretical Molecular Weight 79 kDa
Formulation Supplied as a solution in PBS pH 7.4
Concentration Please refer to the COA for the specific lot.
Storage & Stability Upon receiving, this product remains stable for up to 6 months at -20°C or below. Avoid repeated freeze-thaw cycles.

Background
Target Background SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) also known as 2019-nCoV (2019 Novel Coronavirus) is a virus that causes illnesses ranging from the common cold to severe diseases. SARS-CoV-2 Spike Protein is composed of S1 domain and S2 domain.K417N/T mutation located on the tip of the spike protein, an area important to the antibody recognition process. In some experiments the K417N/T mutation has been associated with decreased antibody recognition and possible resistance to some antibodies. The possibility of a more effective virus/cell binding process has also been described.
Synonyms SARS-CoV-2 S1 protein, K417N; 2019-nCoV S1 protein, K417N

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.