Catalog Products » SARS-CoV-2 Spike protein (RBD, E484K, K417T, N501Y, Avi & His Tag)
SARS-CoV-2 Spike Protein (RBD, E484K, K417T, N501Y, Avi & His Tag)

Immobilized ACE-2 Fc Chimera, Human at 2 μg/mL can bind SARS-CoV-2 Spike protein (RBD, E484K, K417T, N501Y, Avi & His Tag) (Cat. No. Z03600) with a serial dilution.
THETM His Tag Antibody [HRP], mAb, Mouse(Cat.No.A00612) is used as a secondary antibody.

SARS-CoV-2 Spike protein (RBD, E484K, K417T, N501Y, Avi & His Tag)

SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) also known as 2019-nCoV (2019 Novel Coronavirus) is a virus that causes illnesses ranging from the common cold to severe diseases. Lineage P.1, also known as the Brazil(ian) variant is one of the variants of SARS-CoV-2. This variant has 17 amino acid changes, ten of which are in its spike protein, including these three designated to be of particular concern: N501Y, E484K and K417T. SARS-CoV-2 Spike protein (RBD, E484K, K417T, N501Y, Avi & His Tag) carries a Avi Tag followed by a polyhistidine tag at the C-terminus. It has high binding affinity to human chimeric ACE2.
Z03600
$380.00

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Product Introduction
Species SARS-CoV-2
Protein Construction

Expressed with the mutations of E484K, K417N, N501Y.

Spike RBD (Arg319-Ser591)
Accession # P0DTC2		 Avi Poly-His
N-term C-term
Purity > 90% as analyzed by SDS-PAGE
Endotoxin Level < 0.2 EU/μg of protein by gel clotting method
Biological Activity SARS-CoV-2 Spike protein (RBD, E484K, K417T, N501Y, Avi & His Tag) can bind with human ACE2 in functional ELISA assay.
Expression System CHO
Theoretical Molecular Weight 33.7 kDa
Formulation Supplied as a solution in PBS, pH 7.4.
Concentration Please refer to the COA for the specific lot.
Storage & Stability Upon receiving, this product remains stable for up to 6 months at -20°C or below. Please avoid repeated freeze-thaw cycles.

Examples
  • SARS-CoV-2 Spike Protein (RBD, E484K, K417T, N501Y, Avi & His Tag)
    • SARS-CoV-2 Spike Protein (RBD, E484K, K417T, N501Y, Avi & His Tag)

    Immobilized ACE-2 Fc Chimera, Human at 2 μg/mL can bind SARS-CoV-2 Spike protein (RBD, E484K, K417T, N501Y, Avi & His Tag) (Cat. No. Z03600) with a serial dilution.
    THETM His Tag Antibody [HRP], mAb, Mouse(Cat.No.A00612) is used as a secondary antibody.


Background
Target Background SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) also known as 2019-nCoV (2019 Novel Coronavirus) is a virus that causes illnesses ranging from the common cold to severe diseases. Lineage P.1, also known as the Brazil(ian) variant is one of the variants of SARS-CoV-2. This variant has 17 amino acid changes, ten of which are in its spike protein, including these three designated to be of particular concern: N501Y, E484K and K417T. SARS-CoV-2 Spike protein (RBD, E484K, K417T, N501Y, Avi & His Tag) carries a Avi Tag followed by a polyhistidine tag at the C-terminus. It has high binding affinity to human chimeric ACE2.
Synonyms Lineage P.1; 20J/501Y.V3; VOC-202101/02; Brazil(ian) variant; Gamma variant
References 1. Variants: distribution of cases data. GOV.UK. Retrieved 27 February 2021. 
2. COVID-19: Virologist says Brazilian coronavirus variant detected in UK is not the one 'of concern'. 
3. Genomic characterisation of an emergent SARS-CoV-2 lineage in Manaus: preliminary findings. 

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.


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