Catalog Products » SARS-CoV-2 Spike protein (S1, E484K, K417T, N501Y, His Tag)

SARS-CoV-2 Spike protein (S1, E484K, K417T, N501Y, His Tag)

*This product has been discontinued!*
SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) also known as 2019-nCoV (2019 Novel Coronavirus) is a virus that causes illnesses ranging from the common cold to severe diseases. Lineage P.1, also known as the Brazil(ian) variant is one of the variants of SARS-CoV-2. This variant has 17 amino acid changes, ten of which are in its spike protein, including these three designated to be of particular concern: N501Y, E484K and K417T. SARS-CoV-2 Spike protein (S1, E484K, K417T, N501Y, His Tag) carries a polyhistidine tag at the C-terminus.
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Product Introduction
Species SARS-CoV-2
Protein Construction

Expressed with the mutations of E484K, K417T, N501Y.

S1 protein (Gln14-Arg685)
Accession # P0DTC2
Poly-His
N-term C-term
Purity > 95% as analyzed by SDS-PAGE
Endotoxin Level < 0.2 EU/μg of protein by gel clotting method
Biological Activity This protein is validated to bind with human ACE2 in functional ELISA assay.
Expression System CHO
Theoretical Molecular Weight 75.7 kDa
Formulation Supplied as a solution in PBS, pH 7.4.
Concentration Please refer to the COA for the specific lot.
Storage & Stability Upon receiving, this product remains stable for up to 6 months at -20°C or below. Please avoid repeated freeze-thaw cycles.

Background
Target Background SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) also known as 2019-nCoV (2019 Novel Coronavirus) is a virus that causes illnesses ranging from the common cold to severe diseases. Lineage P.1, also known as the Brazil(ian) variant is one of the variants of SARS-CoV-2. This variant has 17 amino acid changes, ten of which are in its spike protein, including these three designated to be of particular concern: N501Y, E484K and K417T. SARS-CoV-2 Spike protein (S1, E484K, K417T, N501Y, His Tag) carries a polyhistidine tag at the C-terminus.
Synonyms Lineage P.1; 20J/501Y.V3; VOC-202101/02; Brazil(ian) variant; Gamma variant
References 1. Variants: distribution of cases data. GOV.UK. Retrieved 27 February 2021. 
2. COVID-19: Virologist says Brazilian coronavirus variant detected in UK is not the one 'of concern'. 
3. Genomic characterisation of an emergent SARS-CoV-2 lineage in Manaus: preliminary findings. 

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.


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