Catalog Products » SARS-CoV-2 Spike protein (S1, W152C, L452R, D614G, His Tag)

SARS-CoV-2 Spike protein (S1, W152C, L452R, D614G, His Tag)

*This product has been discontinued!*
SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) also known as 2019-nCoV (2019 Novel Coronavirus) is a virus that causes illnesses ranging from the common cold to severe diseases. Lineage B.1.429, also known as CAL.20C, with S13I, W152C, L452R mutations in the spike proteins, of which the L452R was of particular concern. B.1.429 is possibly more transmissible, but further study is necessary to confirm this. CDC has listed B.1.429 and the related B.1.427 as "variants of concern," and cites a preprint for saying that they exhibit a ~20% increase in viral transmissibility.
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Product Introduction
Species SARS-CoV-2
Protein Construction

Expressed with the mutations of W152C, L452R, D614G.

S1 protein (Gln14-Arg685)
Accession # P0DTC2		 Poly-His
N-term C-term
Purity > 90% as analyzed by SDS-PAGE
Endotoxin Level < 0.2 EU/μg of protein by gel clotting method
Biological Activity This protein is validated to bind with human ACE2 in functional ELISA assay.
Expression System CHO
Theoretical Molecular Weight 75.7 kDa
Formulation Supplied as a solution in PBS, pH 7.4.
Concentration Please refer to the COA for the specific lot.
Storage & Stability Upon receiving, this product remains stable for up to 6 months at -20°C or below. Please avoid repeated freeze-thaw cycles.

Background
Target Background SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) also known as 2019-nCoV (2019 Novel Coronavirus) is a virus that causes illnesses ranging from the common cold to severe diseases. Lineage B.1.429, also known as CAL.20C, with S13I, W152C, L452R mutations in the spike proteins, of which the L452R was of particular concern. B.1.429 is possibly more transmissible, but further study is necessary to confirm this. CDC has listed B.1.429 and the related B.1.427 as "variants of concern," and cites a preprint for saying that they exhibit a ~20% increase in viral transmissibility.
Synonyms Lineage B.1.429; CAL.20C; B.1.427
References 1. Emergence of a novel SARS-CoV-2 strain in Southern California, USA. 
2. New California Variant May Be Driving Virus Surge There, Study Suggests. 
3. Neutralization of SARS-CoV-2 Variants B.1.429 and B.1.351. 

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.