Catalog Products » SARS-CoV-2 Spike protein (RBD, E484Q, L452R, Avi & His Tag)

SARS-CoV-2 Spike protein (RBD, E484Q, L452R, Avi & His Tag)

*This product has been discontinued!*
SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) also known as 2019-nCoV (2019 Novel Coronavirus) is a virus that causes illnesses ranging from the common cold to severe diseases. Lineage B.1.617, also known as G/452.V3, was first identified in October 2020 in India. This variant has the double mutations E484Q and L452R in the spike proteins. Emerging research suggests the variant may be more transmissible than previously evolved ones. Whether the effectiveness of currently-deployed vaccines is affected remains under investigation. Moreover, the sublineages B.1.617.2 has been redesignated as "variant of concern" (VOC-21APR-02) in May 2021, which spreads more quickly than the original version of the virus.
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Product Introduction
Species SARS-CoV-2
Protein Construction
Spike RBD [Arg319-Ser591 (E484Q, L452R)]
Accession # P0DTC2		 Avi Poly-His
N-term C-term
Purity > 90% as analyzed by SDS-PAGE
Endotoxin Level < 0.2 EU/μg of protein by gel clotting method
Biological Activity This protein is validated to bind with human ACE2 in functional ELISA assay.
Expression System CHO
Theoretical Molecular Weight 33.7 kDa
Formulation Supplied as a solution in PBS, pH 7.4.
Concentration Please refer to the COA for the specific lot.
Storage & Stability Upon receiving, this product remains stable for up to 6 months at -20°C or below. Please avoid repeated freeze-thaw cycles.

Background
Target Background SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) also known as 2019-nCoV (2019 Novel Coronavirus) is a virus that causes illnesses ranging from the common cold to severe diseases. Lineage B.1.617, also known as G/452.V3, was first identified in October 2020 in India. This variant has the double mutations E484Q and L452R in the spike proteins. Emerging research suggests the variant may be more transmissible than previously evolved ones. Whether the effectiveness of currently-deployed vaccines is affected remains under investigation. Moreover, the sublineages B.1.617.2 has been redesignated as "variant of concern" (VOC-21APR-02) in May 2021, which spreads more quickly than the original version of the virus.
Synonyms Lineage B.1.617; G/452.V3; “double mutation" variant; India variant; Kappa variant
References 1. COVID-19 Weekly Epidemiological Update. 
2. Transmission, infectivity, and neutralization of a spike L452R SARS-CoV-2 variant. 
3. SARS-CoV-2 variants of concern and variants under investigation in England. 

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.