Catalog Products » SARS-CoV-2 Spike protein (RBD, E484Q, L452R, Avi & His Tag)

SARS-CoV-2 Spike protein (RBD, E484Q, L452R, Avi & His Tag)

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Overview

Synonyms	Lineage B.1.617; G/452.V3; “double mutation" variant; India variant
Description	SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) also known as 2019-nCoV (2019 Novel Coronavirus) is a virus that causes illnesses ranging from the common cold to severe diseases. Lineage B.1.617, also known as G/452.V3, was first identified in October 2020 in India. This variant has the double mutations E484Q and L452R in the spike proteins. Emerging research suggests the variant may be more transmissible than previously evolved ones. Whether the effectiveness of currently-deployed vaccines is affected remains under investigation. Moreover, the sublineages B.1.617.2 has been redesignated as "variant of concern" (VOC-21APR-02) in May 2021, which spreads more quickly than the original version of the virus.
Accession No	QHD43416.1
Species	SARS-CoV-2
Source	CHO
Tag	C-terminal Avi & His Tag
Biological Activity	This protein is validated to bind with human ACE2 in functional ELISA assay.
Sequence	Arg319-Ser591(E484Q, L452R)

Properties

Molecular Weight	33.7 kDa as predicted from sequence
Purity	>90% as analyzed by SDS-PAGE
Formulation	Liquid
Component	PBS 7.4, 0.5% PC300
Storage	Upon receiving, the product can be stored for 6 months at -20°C or below. Please avoid repeated freeze-thaw cycles.
Note	For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.

Immobilized ACE-2 Fc Chimera, Human at 2 μg/mL can bind SARS-CoV-2 Spike protein (RBD, E484Q, L452R, Avi & His Tag) (Cat.No.Z03607) with a serial dilution.
THE^TM His Tag Antibody [HRP], mAb, Mouse (Cat.No.A00612) is used as a secondary antibody (0.2 μg/mL).