Catalog Products » TNFSF15 Trimer [Biotin], His & Flag, Human

TNFSF15 Trimer [Biotin], His & Flag, Human

TNF superfamily member 15 (TNFSF15), a cytokine largely produced by vascular endothelial cells and a specific inhibitor of the proliferation of these same cells, can inhibit VEGF-induced vascular permeability in vitro and in vivo, and that death receptor 3 (DR3), a cell surface receptor of TNFSF15, mediates TNFSF15-induced dephosphorylation of VEGFR2.
Z04630
$660.00

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Product Introduction
Species Human
Protein Construction
Flag His TNFSF15 Trimer (Asp91-Leu251)
Accession # O95150-1
N-term C-term
Conjugate Biotin
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1 EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized Mouse DR3, His Tag at 5 μg/ml (100 μl/well) on the plate can bind TNFSF15 Trimer [Biotin], His & Flag, Human. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 58.2 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 65-75 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Background
Target Background TNF superfamily member 15 (TNFSF15), a cytokine largely produced by vascular endothelial cells and a specific inhibitor of the proliferation of these same cells, can inhibit VEGF-induced vascular permeability in vitro and in vivo, and that death receptor 3 (DR3), a cell surface receptor of TNFSF15, mediates TNFSF15-induced dephosphorylation of VEGFR2.
Synonyms TL1A; VEGI-251; TNFSF15; TL1; VEGI; VEGI192A

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.