Catalog Products » TIM-1/HAVCR1, His, Cynomolgus

TIM-1/HAVCR1, His, Cynomolgus

Kidney injury molecule 1 (KIM-1, also known as TIM-1) is markedly upregulated in the proximal tubule after injury and is maladaptive when chronically expressed. KIM-1-mediated epithelial cell phagocytosis of apoptotic cells protects the kidney after acute injury by downregulating innate immunity and inflammation.
Z04923
$390.00

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Product Introduction
Species Cynomolgus
Protein Construction
TIM-1/HAVCR1 (Val23-Gly342)
Accession # A0A2K5WXJ6		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 35.25 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 100-150 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Background
Target Background Kidney injury molecule 1 (KIM-1, also known as TIM-1) is markedly upregulated in the proximal tubule after injury and is maladaptive when chronically expressed. KIM-1-mediated epithelial cell phagocytosis of apoptotic cells protects the kidney after acute injury by downregulating innate immunity and inflammation.
Synonyms HAVcr-1; KIM-1; KIM1; TIMD-1; TIMD1;TIM; TIM-1; TIM1; CD365; HAVCR1; HAVCR; HAVCR-1

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.