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Her4/ErbB4, His & Avi, Human

Her4, a member of the EGF receptor family, plays a variety of roles in physiological and pathological states. Genetic studies have indicated a link between Her4 and type 2 diabetes and obesity. Her4 may play an important role in glucose homeostasis and lipogenesis. Her4 deficiency-related obesity and adipose tissue inflammation may contribute to the development of MetS.
$280.00
Z05372-100

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Product Introduction
Species Human
Protein Construction
Her4/ErbB4 (Gln26-Pro651)
Accession # Q15303-1		 His Avi
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 72.7 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 80-110 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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Her4/ErbB4, His & Avi, Human

Immobilized Her4/ErbB4, His & Avi, Human, His Tag at 2 μg/ml (100 μl/well) on the plate. Dose response curve for Human NRG1 Beta 1, hFc Tag with the EC50 of 8.2ng/ml determined by ELISA. »

Her4/ErbB4, His & Avi, Human

The purity of Her4/ErbB4, His & Avi, Human is greater than 95% as determined by SEC-HPLC. »

Her4/ErbB4, His & Avi, Human

Her4/ErbB4, His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

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Background
Target Background Her4, a member of the EGF receptor family, plays a variety of roles in physiological and pathological states. Genetic studies have indicated a link between Her4 and type 2 diabetes and obesity. Her4 may play an important role in glucose homeostasis and lipogenesis. Her4 deficiency-related obesity and adipose tissue inflammation may contribute to the development of MetS.
Synonyms p180erbB4; 4ICD; E4ICD; HER4; ErbB4; MGC138404; ALS19
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.