Overview

Tight junctions establish the paracellular barrier that controls the flow of molecules in the intercellular space between the cells of an epithelium [1][2]. Claudins are crucial components of tight junctions. They are small (20-27 (kDa)) [3] transmembrane proteins containing typically four transmembrane domains and two extracellular loops (figure 1). The claudin family consists of approximately 27 proteins that locate differentially in different tissues. Their altered function has been linked to various cancers [4], which makes them potential targets for diagnostics and therapeutic modalities.

Figure 1. Model structure of claudin protein.
Retrieved from reference 11.

Claudin 18.2 is the isoform 2 of Claudin-18 protein. Its expression in normal tissues is strictly confined to differentiated epithelial cells of the gastric mucosa [5]. However, CLDN18.2 is highly expressed in certain primary malignant tumors, such as gastric cancer (GC) [6], breast cancer, colon cancer and liver cancer. Its expression is also present in pancreatic, esophageal, ovarian, and pulmonary tumors. Its abnormal expression in various epithelial tumors indicates that CLDN18.2 may play an important role in tumor invasion and metastasis.

CLDN18.2 is often linked with proliferation and chemotaxis of cells in gastric cancer. According to Globocan 2020 data, gastric cancer is the fifth most frequently diagnosed cancer, over one million new cases of gastric cancer are diagnosed worldwide. Gastric cancer is a heterogenous disease characterized by expression of specific proteins, including MUC17, CLDN18.2, receptor tyrosine kinases (e.g., HER2), and growth factors (e.g., VEGF) [7, 8, 9]. CLDN18.2 is expressed in 50 - 70% of primary gastric adenocarcinomas and their metastases, thus it is considered a promising candidate for targeted GC therapy [10].

GenScript has developed a panel of recombinant CLDN18.2 proteins, CLDN18.2 Stable Cell Lines, and related reagents to facilitate the CLDN18.2-related research projects.

Products

Recombinant Proteins

  • Full-length
  • Active membrane protein
  • Consistent Supply

Stable Cell Lines

  • Single-clone derived
  • Overexpression guarantee
  • Stable over 15 passages
Cat. No. Product Name Quantity Price Order
A02180
MonoRab™ Claudin 18.2 Antibody (126C1), mAb, Rabbit
$215.00 40 μg
 
M00916
CHO-K1/CLDN18.2 Stable Cell Line
$8500.00 2 vials
 
M00917
HEK293/CLDN18.2 Stable Cell Line
$8500.00 2 vials
 
Z03504
CLDN18.2, His, Human
$220.00
 
Z03709
CLDN18.2, hFc, Human
$1500.00
 

Applications

Screening antibody-based drug candidates binding with CLDN18.2.

Using as immunogen for anti-CLDN18.2 antibody development.

Product Performance

Related Products

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CHO-K1/CD16A 158V Stable Cell Line
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CHO-K1/human CD32A 131His Stable Cell Line
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M00600
CHO-K1/CD32B 232Thr Stable Cell Line
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CHO-K1/CD32C 13Gln Stable Cell Line
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M00602
CHO-K1/CD16B NA1 Stable Cell Line
$8925.00 2 vials
 
M00603
CHO-K1/FcRn Stable Cell Line
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Z02689
VEGF165, Human
$95.00
 
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VEGF164, Rat (CHO-expressed)
$95.00
 
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PD-1 Fc Chimera, Human
$120.00
 
Z03373
CTLA-4 Fc Chimera, Human
$65.00
 

CLDN18.2 Clinical Trials and Therapies

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