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Integrative in silico and biochemical analyses demonstrate direct Arl3-mediated ODA16 release from the intraflagellar transport machinery
Authors: Jiaolong Wang, Rune T Kidmose, Niels Boegholm, Nevin K Zacharia, Mads B Thomsen, Anni Christensen, Tara Malik, Karl Lechtreck, Esben Lorentzen
Journal: The Journal of Biological Chemistry
PubMed ID: 39880089
Doi: 10.1016/j.jbc.2025.108237
Products & Services: Gene Synthesis   Codon Optimization   
Structure and dynamics of GAD65 in complex with an autoimmune polyendocrine syndrome type 2-associated autoantibody
Authors: Susanne H D Ständer, Cyril F Reboul, Sarah N Le, Daniel E Williams, Peter G Chandler, Mauricio G S Costa, David E Hoke, John D T Jimma, James Fodor, Gustavo Fenalti, Stuart I Mannering, Benjamin T Porebski, Peter Schofield, Daniel Christ, Malcolm Buckle, Sheena McGowan, Dominika Elmlund, Kasper D Rand, Ashley M Buckle
Journal: Nature Communications
PubMed ID: 40055307
Doi: 10.1038/s41467-025-57492-4
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SUMO4 promotes SUMO deconjugation required for DNA double-strand-break repair
Authors: Alexander J Garvin, Alexander J Lanz, George E Ronson, Matthew J W Mackintosh, Katarzyna Starowicz, Alexandra K Walker, Yara Aghabi, Hannah MacKay, Ruth M Densham, Jai S Bhachoo, Aneika C Leney, Joanna R Morris
Journal: Mol Cell
PubMed ID: 40054443
Doi: 10.1016/j.molcel.2025.02.004
ER nests are specialized ER subdomains in Arabidopsis where peroxisomes and lipid droplets form
Authors: Zachary J Wright , Nathan E Tharp , Bonnie Bartel
Journal: Developmental Cell
Doi: 10.1016/j.devcel.2025.03.005
Products & Services: Gene Synthesis   Protein Electrophoresis and Western   
Structural mechanisms underlying the modulation of CXCR4 by diverse small-molecule antagonists
Authors: Xiaohong Sang, Haizhan Jiao, Qian Meng, Xiong Fang, Qi Pan, Jiao Zhou, Tingli Qian, Wanqin Zhang, Yan Xu, Jing An, Ziwei Huang, Hongli Hu
Journal: Proceedings of the National Academy of Sciences of the United States of America
PubMed ID: 40063796
Doi: 10.1073/pnas.2425795122
Products & Services: Gene Synthesis   
Immunomodulatory role of the stem cell circadian clock in muscle repair
Authors: Pei Zhu, Eric M Pfrender, Adam W T Steffeck, Colleen R Reczek, Yalu Zhou, Abhishek Vijay Thakkar, Neha R Gupta, Ariana Kupai, Amber Willbanks, Richard L Lieber, Ishan Roy, Navdeep S Chandel, Clara B Peek
Journal: SCIENCE ADVANCES
PubMed ID: 40043110
Doi: 10.1126/sciadv.adq8538
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A globular protein exhibits rare phase behavior and forms chemically regulated orthogonal condensates in cells
Authors: Jinglei Nie, Xinyi Zhang, Zhijuan Hu, Wei Wang, Martin A Schroer, Jie Ren, Dmitri Svergun, Anyang Chen, Peiguo Yang, An-Ping Zeng
Journal: Nature Communications
PubMed ID: 40069234
Doi: 10.1038/s41467-025-57886-4
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Rational Design Assisted by Evolutionary Engineering Allows (De)Construction and Optimization of Complex Phenotypes in Pseudomonas putida KT2440
Authors: Blas Blázquez, Juan Nogales
Journal: Microbial biotechnology
PubMed ID: 40126873
Doi: 10.1111/1751-7915.70132
Products & Services: Gene Synthesis   
Structure-Guided Development of Chemically Tailored Peptide Binders of RNF43/ZNRF3 to Enable Versatile Design of Membrane Protein-Targeting PROTACs
Authors: Jibin Cui , Qingyun Zheng , Yicheng Weng , Xiaoguo Zhai , Zhen Su , Yunxiang Du , Xiaoxiong Wei , Yuanyuan Yu , Qian Qu , Man Pan
Journal: Analytical Chemistry
PubMed ID: 40000409
Doi: doi.org/10.1002/anie.202501488
Products & Services: Codon Optimization   Gene Synthesis   
Activation of the bacterial defenseassociated sirtuin system
Authors: Kaixiang Zhu, Kun Shang, Linyue Wang, Xia Yu, Lei Hua, Weihe Zhang, Bo Qin, Jia Wang, Xiaopan Gao, Hongtao Zhu, Sheng Cui
Journal: Communications Biology
PubMed ID: 39994439
Doi: doi.org/10.1038/s42003-025-07743-3
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