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Structural visualization of HECT-type E3 ligase Ufd4 accepting and transferring
Authors: Xiangwei Wu, Huasong Ai, Junxiong Mao, Hongyi Cai, Lu-Jun Liang, Zebin Tong, Zhiheng Deng, Qingyun Zheng, Lei Liu, Man Pan
Journal: nature COMMUNICATION
PubMed ID: 40341121
Doi: doi.org/10.1038/s41467-025-59569-6
Products & Services: Gene Synthesis   Codon Optimization   PCR Cloning and Subcloning   Mutagenesis Services   
SUMO4 promotes SUMO deconjugation required for DNA double-strand-break repair
Authors: Alexander J Garvin, Alexander J Lanz, George E Ronson, Matthew J W Mackintosh, Katarzyna Starowicz, Alexandra K Walker, Yara Aghabi, Hannah MacKay, Ruth M Densham, Jai S Bhachoo, Aneika C Leney, Joanna R Morris
Journal: Mol Cell
PubMed ID: 40054443
Doi: 10.1016/j.molcel.2025.02.004
Products & Services: Gene Synthesis   Mutagenesis Services   PCR Cloning and Subcloning   Peptide Synthesis   
Ligand-Responsive Artificial Protein–Protein Communication for Field-Deployable Cell-Free Biosensing
Authors: Ke Wang , Siqian Liu , Shuqi Zhou , Aori Qileng , Dingyi Wang , Yingju Liu , Chunlai Chen , Chunyang Lei , Zhou Nie
Journal: Angew Chem Int Ed Engl
PubMed ID: 39558180
Doi: 10.1002/anie.202416671
Products & Services: PCR Cloning and Subcloning   
Direct repeat region 3’ end modifications regulate Cas12a activity and expand its applications
Authors: Wei Zhang , Yinyin Zhong , Jiaqi Wang , Guangrong Zou , Qiaozhen Chen , Chaoxing Liu
Journal: Nucleic Acids Res
PubMed ID: 39883010
Doi: 10.1093/nar/gkaf040
Products & Services: PCR Cloning and Subcloning   
Multiplexed Assays of Variant Effect and Automated Patch Clamping Improve KCNH2-LQTS Variant Classification and Cardiac Event Risk Stratification
Authors: Matthew J O'Neill, Chai-Ann Ng, Takanori Aizawa, Luca Sala, Sahej Bains, Annika Winbo, Rizwan Ullah, Qianyi Shen, Chek-Ying Tan, Krystian Kozek, Loren R Vanags, Devyn W Mitchell, Alex Shen, Yuko Wada, Asami Kashiwa, Lia Crotti, Federica Dagradi, Giulia Musu, Carla Spazzolini, Raquel Neves, J Martijn Bos, John R Giudicessi, Xavier Bledsoe, Eric R Gamazon, Megan C Lancaster, Andrew M Glazer, Bjorn C Knollmann, Dan M Roden, Jochen Weile, Frederick Roth, Joe-Elie Salem, Nikki Earle, Rachael Stiles, Taylor Agee, Christopher N Johnson, Minoru Horie, Jonathan R Skinner, Michael J Ackerman, Peter J Schwartz, Seiko Ohno, Jamie I Vandenberg, Brett M Kroncke
Journal: Circulation
PubMed ID: 39315434
Doi: 10.1161/CIRCULATIONAHA.124.069828
Products & Services: PCR Cloning and Subcloning   
Two riboswitch classes that share a common ligand-binding fold show major differences in the ability to accommodate mutations
Authors: Yoshita Srivastava , Olayinka Akinyemi , Tiana C Rohe , Elizabeth M Pritchett , Cameron D Baker , Akshara Sharma , Jermaine L Jenkins , David H Mathews , Joseph E Wedekind
Journal: Nucleic Acids Research
PubMed ID: 39413212
Doi: 10.1093/nar/gkae886
Products & Services: Single-Stranded DNA Synthesis   PCR Cloning and Subcloning   Mutagenesis Services   
Mechanism of nucleosomal H2A K13/15 monoubiquitination and adjacent dual monoubiquitination by RNF168
Authors: Huasong Ai , Zebin Tong , Zhiheng Deng , Qiang Shi, Shixian Tao , Gaoge Sun, Jiawei Liang , Maoshen Sun , Xiangwei Wu , Qingyun Zheng , Lujun Liang , Hang Yin , Jia-Bin Li , Shuai Gao , Changlin Tian , Lei Liu , Man Pan
Journal: Nature Chemical Biology
PubMed ID: 39394267
Doi: doi.org/10.1038/s41589-024-01750-x
Products & Services: Gene Synthesis   PCR and Cloning   
Reduced Cross-Protective Potential of Omicron Compared to Ancestral SARS-CoV-2 Spike Vaccines Against Potentially Zoonotic Coronaviruses
Authors: Tyler RennerMatthew StuibleBrian CassSylvie PerretJulie GuimondSimon Lord-DufourMichael J. McCluskieYves DurocherBassel Akache
Journal: npj Viruses
Doi: doi.org/10.21203/rs.3.rs-4791122/v1
Products & Services: Gene Synthesis   PCR Cloning and Subcloning   
Highly sensitive and selective electrochemical biosensor using odorant-binding protein to detect aldehydes
Authors: Cong Peng a b, Yutong Sui a, Chaohua Fang a, Hongxu Sun a, Wenxin Liu a, Xinying Li a, Chen Qu a, Wenhui Li a, Jiemin Liu a c, Chuandong Wu a
Journal: Analytica Chimica Acta
Doi: 10.1016/j.aca.2024.342932
Products & Services: PCR Cloning and Subcloning   
Engineering psychrophilic polymerase for nanopore long-read sequencing
Authors: Yaping Sun , Danny Hsu Ko , Jie Gao , Kang Fu , Yuanchen Mao , Yun He , Hui Tian
Journal: Front Bioeng Biotechnol
PubMed ID: 39011153
Doi: 10.3389/fbioe.2024.1406722
Products & Services: PCR Cloning and Subcloning   
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