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Dictating the spatial-temporal delivery of molecular adjuvant and antigen for the enhanced vaccination
Authors: Yumeng Yan , Xiaonan Huang , Lili Yuan , To Ngai , Guanghui Ma , Yufei Xia
Journal: Biomaterials
PubMed ID: 38968687
Doi: 10.1016/j.biomaterials.2024.122697
Products & Services: Peptide Synthesis   
Rational design of a DNA-launched live attenuated vaccine against human enterovirus 71
Authors: Rong-Rong Zhang 1, Meng-Jiao He 1, Chao Zhou 1, Yan-Peng Xu 1, Wei Tang 1, Tian-Shu Cao 1, Zheng-Jian Wang , Mei Wu , Tao Ming , Yi-Jiao Huang , Meng-Xu Sun , Hui Zhao , Yong-Qiang Deng , Xiao-Feng Li , Bin Wang , Qing Ye , Cheng-Feng Qin
Journal: VIROLOGICA SINICA
PubMed ID: 39306193
Doi: 10.1016/j.virs.2024.09.008
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Accelerated discovery and miniaturization of novel single-stranded cytidine deaminases
Authors: Jiacheng Deng,† , Xueyuan Li,† , Hao Yu,† , Lin Yang1, Ziru Wang1, Wenfeng Yi, Ying Liu, Wenyu Xiao, Hongyong Xiang, Zicong Xie, Dongmei Lv, Hongsheng Ouyang, Daxin Pang, * and Hongming Yuan
Journal: Nucleic Acids Research
PubMed ID: 39271120
Doi: doi.org/10.1093/nar/gkae800
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Crystal structure and nucleic acid binding mode of CPV NSP9: implications for viroplasm in Reovirales
Authors: Yeda Wang , Hangtian Guo , Yuhao Lu , Wanbin Yang , Tinghan Li , Xiaoyun Ji
Journal: Nucleic Acids Research
PubMed ID: 39287123
Doi: doi.org/10.1093/nar/gkae803
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Targeting Ras-, Rho-, and Rab-family GTPases via a conserved cryptic pocket
Authors: Johannes Morstein , Victoria Bowcut , Micah Fernando , Yue Yang , Lawrence Zhu , Meredith L Jenkins , John T Evans , Keelan Z Guiley , D Matthew Peacock , Sophie Krahnke , Zhi Lin , Katrine A Taran , Benjamin J Huang , Andrew G Stephen , John E Burke , Felice C Lightstone , Kevan M Shokat
Journal: Cell
PubMed ID: 39255801
Doi: 10.1016/j.cell.2024.08.017
Products & Services: DNA Sequencing   
Photoexcited Cryptochrome 1 Interacts With SPCHLESS to Regulate Stomatal Development in Arabidopsis
Authors: Li Chen 1 2, Xiaoli Cao , Yupeng Li 1 2, Minqing Liu 1, Yao Liu 1, Yan Guan 1 2, Jiaqi Ruan 1, Zhilei Mao 1 2, Wenxiu Wang 1 2, Hong-Quan Yang 1 2, Tongtong Guo
Journal: PLANT CELL AND ENVIRONMENT
PubMed ID: 39253954
Doi: 10.1111/pce.15123
In Situ Noninvasive Monitoring of Cell Secretions Based on MOFs/AAO Hybrid Membrane Induced Asymmetric Ion Transport
Authors: Zhaohan Wang , Yafeng Wu , Zhi Wang , Zhaoyan Tian , Yu Liu , Songqin Liu
Journal: Biosensors & bioelectronics
Doi: 10.1016/j.bios.2024.116735
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PICKLE-mediated nucleosome condensing drives H3K27me3 spreading for the inheritance of Polycomb memory during differentiation
Authors: Zhenwei Liang, ∙ Tao Zhu, ∙ Yaoguang Yu,∙ … ∙ Yuhai Cui ∙ Shangzhi Huang ∙ Chenlong Li
Journal: Molecular Cell
Doi: doi.org/10.1016/j.molcel.2024.08.018
Products & Services: Molecular Biology Reagents   
Inhalation of Bioorthogonal Gene-Editable Spiky-Pollen Reprograms Tumor-Associated Macrophages for Lung Cancer Immunotherapy
Authors: Qianglan Lu , Ruiyue Chen , Fei Zeng, Zhiyong Liu, Yongchun Pan, Yanfeng Gao, Bangshun He and Yujun Song
Journal: Advanced Functional Materials
Doi: 10.1002/adfm.202408767
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Identification of an RNA-binding perturbing characteristic for thiopurine drugs and their derivatives to disrupt CELF1–RNA interaction
Authors: Yang Tan , Zhibo Zhao , Qingfang Han , Peipei Xu , Xiaopeng Shen , Yajun Jiang , Qiang Xu , Xingxin Wu
Journal: Nucleic Acids Research
PubMed ID: 39268573
Doi: 10.1093/nar/gkae788
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Tuning the fluidity and protein corona of ultrasound-responsive liposomal nanovaccines to program T cell immunity in mice
Authors: Jia He , Chaoyu Wang , Xiao Fang , Junyao Li , Xueying Shen , Junxia Zhang , Cheng Peng , Hongjian Li , Sai Li , Jeffrey M Karp , Rui Kuai
Journal: Nature Communications
PubMed ID: 39284814
Doi: 10.1038/s41467-024-52104-z
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Mitochondrial rewiring with small-molecule drug-free nanoassemblies unleashes anticancer immunity
Authors: Lulu Ren , Jianqin Wan , Xiaoyan Li , Jie Yao , Yan Ma , Fanchao Meng , Shusen Zheng , Weidong Han , Hangxiang Wang
Journal: Nature Communications
PubMed ID: 39227567
Doi: 10.1038/s41467-024-51945-y
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EXTL3 and NPC1 are mammalian host factors for Autographa californica multiple nucleopolyhedrovirus infection
Authors: Yuege Huang , Hong Mei , Chunchen Deng , Wei Wang , Chao Yuan , Yan Nie , Jia-Da Li , Jia Liu
Journal: Nature Communications
PubMed ID: 39231976
Doi: 10.1038/s41467-024-52193-w
A bioorthogonal probiotic platform spatiotemporally releases nanobodies in deep tumor for cancer chemoimmunotherapy
Authors: Ruiyue Chen , Qianglan Lu , Fei Zeng , Shurong Qin , Yongchun Pan , Zhiyong Liu , Yuzhen Wang , Bangshun He , Wenjin Qi , Yujun Song
Journal: Materials Today
Doi: 10.1016/j.mattod.2024.09.002
Products & Services: Recombinant Proteins   
Open-Source Throttling of CD8+ T Cells in Brain with Low-Intensity Focused Ultrasound-Guided Sequential Delivery of CXCL10, IL-2, and aPD-L1 for Glioblastoma Immunotherapy
Authors: Lei Dong , Yini Zhu , Haoge Zhang , Lin Gao , Zhiqi Zhang , Xiaoxuan Xu , Leqian Ying , Lu Zhang , Yue Li , Zhengcheng Yun , Danqi Zhu , Chang Han , Tingting Xu , Hui Yang , Shenghong Ju , Xiaoyuan Chen , Haijun Zhang , Jinbing Xie
Journal: ADVANCED MATERIALS
PubMed ID: 39264011
Doi: 10.1002/adma.202407235
Products & Services: Recombinant Proteins   
Strontium-Modified porous attapulgite composite hydrogel scaffold with advanced angiogenic and osteogenic potential for bone defect repair
Authors: Chun Liu , Su Ni , Xiaoyu Wu , Linxiang Zhang , Ting Dai , Aiqin Wang , Hongbin Zhao
Journal: COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING
Doi: doi.org/10.1016/j.compositesa.2024.108492
Arabidopsis cryptochromes interact with SOG1 to promote the repair of DNA double-strand breaks
Authors: Li Chen , Minqing Liu , Yupeng Li , Yan Guan, Jiaqi Ruan , Zhilei Mao , Wenxiu Wang , Hong-Quan Yang , Tongtong Guo
Journal: BBRC
Doi: 10.1016/j.bbrc.2024.150233
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The 8-oxoguanine DNA glycosylase-synaptotagmin 7 pathway increases extracellular vesicle release and promotes tumour metastasis during oxidative stress
Authors: Ying Ma , Jiarong Guo , Haipeng Rao , Jingyu Xin , Xinyi Song , Rui Liu , Shan Shao , Jiajia Hou , Liyu Kong , Zhigang Hu , Lingfeng He , Feiyan Pan , Zhigang Guo
Journal: Journal of extracellular vesicles
PubMed ID: 39235072
Doi: 10.1002/jev2.12505
Products & Services: Gene Synthesis   
Chemoproteomic profiling unveils binding and functional diversity of endogenous proteins that interact with endogenous triplex DNA
Authors: Hongzhan Xu , Jing Ye # , Kui-Xing Zhang # , Qingxi Hu , Tongxiao Cui , Chong Tong , Mengqi Wang , Huichao Geng , Kun-Ming Shui , Yan Sun , Jian Wang , Xiaomeng Hou , Kai Zhang , Ran Xie , Yafei Yin , Nan Chen , Jia-Yu Chen
Journal: nature Chemistry
PubMed ID: 39223307
Doi: 10.1038/s41557-024-01609-7
Products & Services: Catalog Peptides   
OsFAD1–OsMYBR22 modulates clustered spikelet through regulating BRD3 in rice
Authors: Mingxing Cheng , Huanran Yuan , Ruihua Wang , Fengfeng Fan , Fengfeng Si , Xiong Luo , Wei Liu , Shaoqing Li
Journal: Journal of integrative plant biology
PubMed ID: 39279451
Doi: doi.org/10.1111/jipb.13775
Products & Services: Peptide Synthesis   
Clathrin-associated carriers enable recycling through a kiss-and-run mechanism
Authors: Jiachao Xu, Yu Liang, Nan Li, Song Dang, Amin Jiang, Yiqun Liu, Yuting Guo, Xiaoyu Yang, Yi Yuan, Xinyi Zhang, Yaran Yang, Yongtao Du, Anbing Shi, Xiaoyun Liu, Dong Li, Kangmin He
Journal: Nature Cell Biology
PubMed ID: 39300312
Doi: 10.1038/s41556-024-01499-4
Products & Services: Molecular Biology Reagents   
A two-pronged nanostrategy of iron metabolism disruption to synergize tumor therapy by triggering the paraptosis-apoptosis hybrid pathway
Authors: Huali Lei , Guanghui Hou , Lin Liu , Zifan Pei , Youdong Chen , Yujie Lu , Nalin Yang , Shumin Sun , Liang Cheng
Journal: ACS Nano
PubMed ID: 39121010
Doi: 10.1021/acsnano.4c06199
Products & Services: Peptide Synthesis   
25-Hydroxycholesterol inhibits Hantavirus infection by reprogramming cholesterol metabolism
Authors: Yamei Dang , Yuan Wang , Jing Wei , Hui Zhang , Qiqi Yang , Bin Wang , Jia Li , Chuantao Ye , Yang Chen , Peijun Han , Xiaolei Jin , Jia Wang , Xiaohui Bao , He Liu , Hongwei Ma , Liang Zhang , Linfeng Cheng , Yangchao Dong , Yinlan Bai , Yinghui Li , Yingfeng Lei , Zhikai Xu , Fanglin Zhang , Wei Ye
Journal: FREE RADICAL BIOLOGY AND MEDICINE
PubMed ID: 39209137
Doi: 10.1016/j.freeradbiomed.2024.08.029
Products & Services: Codon Optimization   
Activation of ATF3 via the integrated stress response pathway regulates innate immune response to restrict Zika virus
Authors: Pheonah Badu , Gabriele Baniulyte , Morgan A Sammons , Cara T Pager
Journal: Virology Journal
PubMed ID: 39212382
Doi: 10.1128/jvi.01055-24
Products & Services: CRISPR RNAs/Cas9 Proteins(INACTIVE)   
Proteasome gene expression is controlled by coordinated functions of multiple transcription factors
Authors: Jennifer E Gilda, Asrafun Nahar, Dharanibalan Kasiviswanathan, Nadav Tropp, Tamar Gilinski, Tamar Lahav, Dina Alexandrovich, Yael Mandel-Gutfreund, Soyeon Park, Shenhav Shemer
Journal: J Cell Biol
PubMed ID: 38767572
Doi: 10.1083/jcb.202402046
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A metal anion strategy to induce pyroptosis combined with STING activation to synergistically amplify anti-tumor immunity
Authors: Zifan Pei , Nan Jiang , Fei Gong , Weihao Yang , Jiachen Xu , Bin Yu , Nailin Yang , Jie Wu , Huali Lei , Shumin Sun , Longxiao Li , Zhicheng Liu , Caifang Ni , Liang Cheng
Journal: Materials Today
Doi: 10.1016/j.mattod.2024.07.013
Secreted PTEN binds PLXDC2 on macrophages to drive antitumor immunity and tumor suppression
Authors: Cheng Zhang , Hong-Ming Ma , Shuai Wu , Jia-Ming Shen , Na Zhang , Yi-Lu Xu , Cheng-Xiao Li , Ping He , Meng-Kai Ge , Xi-Li Chu , Yu-Xue Zhang , Jun-Ke Zheng , Guo-Qiang Chen , Shao-Ming Shen
Journal: Developmental Cell
PubMed ID: 39197453
Doi: 10.1016/j.devcel.2024.08.003
Activation mechanisms of dimeric mechanosensitive OSCA/TMEM63 channels
Authors: Yuanyue Shan , Mengmeng Zhang , Meiyu Chen , Xinyi Guo , Ying Li , Mingfeng Zhang , Duanqing Pei
Journal: Nature Communications
PubMed ID: 39209849
Doi: 10.1038/s41467-024-51800-0.
A low-molecular-weight α-glucan from edible fungus Agaricus blazei Murrill activates macrophage TFEB-mediated antibacterial defense to combat implant-associated infection
Authors: Qishan Wang , Yuehong Wang , Yihao Liu , Kai Yuan , Yixuan Lin , Xian Qian , Hongyan Pei , Liangliang Weng , Kaijian Fan , Yihe Hu , Yiqi Yang
Journal: Carbohydrate Polymers
Doi: 10.1016/j.carbpol.2024.122659
Spatiotemporal coordination of antigen presentation and co-stimulatory signal for enhanced anti-tumor vaccination
Authors: Sha Peng , Yumeng Yan , Kenji Ogino , Guanghui Ma , Yufei Xia
Journal: Journal of controlled release
PubMed ID: 39153722
Doi: 10.1016/j.jconrel.2024.08.025.
Products & Services: Peptoid Synthesis   
Rupatadine-inhibited OTUD3 promotes DLBCL progression and immune evasion through deubiquitinating MYL12A and PD-L1
Authors: Ying Sui , Ziyang Shen, Xiaoyou Li 1, Ya Lu , SiTong Feng , Rong Ma, Jianzhong Wu , Changwen Jing, Zhuo Wang, Jifeng Feng , Haixia Cao
Journal: Cell death & disease
PubMed ID: 39097608
Doi: 10.038/s41419-024-06941-x
siRNA nanoparticle targeting Usp20 lowers lipid levels and ameliorates metabolic syndrome in mice
Authors: Yi Ding 1, Qiu-Bing Chen , Hui Xu , Dilare Adi , Yi-Wen Ding , Wen-Jun Luo , Wen-Zhuo Zhu , Jia-Chen Xu , Xiaolu Zhao , Xiong-Jie Shi , Jie Luo , Hao Yin , Xiao-Yi Lu
Journal: Journal of lipid research
PubMed ID: 39173829
Doi: 10.1016/j.jlr.2024.100626
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Channelrhodopsins with distinct chromophores and binding patterns
Authors: Yuanyue Shan , Liping Zhao , Meiyu Chen , Xiao Li , Mingfeng Zhang , Duanqing Pei
Journal: Nature Communications
PubMed ID: 39181878
Doi: 10.1038/s41467-024-51811-x
hypocretin-1/hypocretin receptor 1 regulates neuroplasticity and cognitive function through hippocampal lactate homeostasis in depressed model
Authors: Bing Chen , Kangyu Jin , Jingyi Dong , Shangping Cheng , Lingzhuo Kong , Shaohua Hu , Zuobing Chen, Jing Lu
Journal: Advanced Science
PubMed ID: 39119889
Doi: 10.1002/advs.202405354
Anattachment glycoprotein nanoparticle elicits broadly neutralizing antibodies and protects against lethal Nipah virus infection
Authors: Dan Zhou , Rao Cheng , Yanfeng Yao , Gan Zhang , Xin Li , Bingjie Wang , Yong Wang , Feiyang Yu , Shangyu Yang , Hang Liu , Ge Gao , Yun Peng , Miaoyu Chen , Zengqin Deng , Haiyan Zhao
Journal: npj Vaccines
PubMed ID: 39217188
Doi: 10.1038/s41541-024-00954-5
Highly sensitive and selective electrochemical biosensor using odorant-binding protein to detect aldehydes
Authors: Cong Peng a b, Yutong Sui a, Chaohua Fang a, Hongxu Sun a, Wenxin Liu a, Xinying Li a, Chen Qu a, Wenhui Li a, Jiemin Liu a c, Chuandong Wu a
Journal: Analytica Chimica Acta
Doi: 10.1016/j.aca.2024.342932
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CLASP-mediated competitive binding in protein condensates directs microtubule growth
Authors: Xuanyan Jia , Leishu Lin, Siqi Guo , Lulu Zhou , Gaowei Jin , Jiayuan Dong , Jinman Xiao , Xingqiao Xie , Yiming Li , Sicong He , Zhiyi Wei , Cong Yu
Journal: Nature Communications
PubMed ID: 39095354
Doi: 10.1038/s41467-024-50863-3
Simultaneous In Vivo Imaging of Neutrophil Elastase and Oxidative Stress in Atherosclerotic Plaques Using a Unimolecular Photoacoustic Probe
Authors: Yuan Ma , Hui Cao , Baode Chen , Xinyu Xu , Qingpeng Zhang , Haoming Chen , Xiao-Bing Zhang , Guosheng Song
Journal: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
PubMed ID: 39115358
Doi: 10.1002/anie.202411840
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A broadly protective antibody targeting glycoprotein Gn inhibits severe fever with thrombocytopenia syndrome virus infection
Authors: Xuanxiu Ren # 1, Jiawen Sun # 2 3, Wenhua Kuang # 2, Feiyang Yu 1, Bingjie Wang 1, Yong Wang 2 3, Wei Deng 2 3, Zhao Xu 2 3, Shangyu Yang 1, Hualin Wang 2 4, Yangbo Hu 2 4, Zengqin Deng 5 6, Yun-Jia Ning 7 8, Haiyan Zhao
Journal: Nature Communications
PubMed ID: 39147753
Doi: 10.1038/s41467-024-51108-z
Lipid synthesis, triggered by PPARγ T166 dephosphorylation, sustains reparative function of macrophages during tissue repair
Authors: Shiman Zuo , Yuxin Wang , Hanjing Bao , Zehui Zhang , Nanfei Yang , Meng Jia , Qing Zhang , Ani Jian , Rong Ji , Lidan Zhang , Yan Lu , Yahong Huang , Pingping Shen
Journal: Nature Communications
PubMed ID: 39179603
Doi: doi.org/10.1038/s41467-024-51736-5
Products & Services: Gene Synthesis   
Zinc Coordination Lipid Nanoparticles Co-Delivering Calcium Peroxide and Chelating STING agonist for Enhanced Cancer Metalloimmunotherapy
Authors: Qian Qiu , Jiexin Li , He Ren , Jingyu Zhang , Gengqi Liu , Ruiqi Yang , Boyang Sun , Chen Zhang , Yumiao Zhang
Journal: Small
PubMed ID: 39114869
Doi: 10.1002/smll.202402308
Products & Services: Recombinant Proteins   
Enzyme-Dynamic Extracellular Vesicles for Metalloimmunotherapy of Malignant Pleural Effusions
Authors: Jiexin Li , Ruiqi Yang , Fuqiang Dong , Qian Qiu , Zhen Jiang , He Ren , Chen Zhang , Gengqi Liu , Jonathan F Lovell , Yumiao Zhang
Journal: ACS Nano
PubMed ID: 39109520
Doi: 10.1021/acsnano.3c12375
Products & Services: Recombinant Antibody Expression   
OPALIN is an LGI1 receptor promoting oligodendrocyte differentiation
Authors: Xiao-Yu Teng , Ping Hu , Cai-Ming Zhang , Qin-Xin Zhang , Guolin Yang , Yan-Yu Zang , Zhi-Xiong Liu , Guiquan Chen , Yun Stone Shi
Journal: Proceedings of the National Academy of Sciences of the United States of America
PubMed ID: 39083419
Doi: 10.1073/pnas.2403652121
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A Minimalist Pathogen-Like Sugar Nanovaccine for Enhanced Cancer Immunotherapy
Authors: Yu Miao , Le Niu , Xinying Lv , Qiang Zhang , Zhisheng Xiao , Zhaoxin Ji , Linfu Chen , Yi Liu , Nanhui Liu , Junjie Zhu , Yang Yang , Qian Chen
Journal: ADVANCED MATERIALS
PubMed ID: 39210649
Doi: 10.1002/adma.202410715
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Peptide degrader-based targeting of METTL3/14 improves immunotherapy response in cutaneous melanoma
Authors: Hong Han , Zenghui Li , Yuqing Feng , He Song , Zhixiong Fang , Dingxiao Zhang , Dan Yuan , Junfeng Shi
Journal: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
PubMed ID: 39136347
Doi: doi.org/10.1002/anie.202407381
Products & Services: Recombinant Proteins   
The Effects of the Carrier and Ligand Spatial Conformation on RNA Nanodrug Cell Delivery
Authors: Zhuang Zhang , Siying Li , Hongda Wang , Yuping Shan
Journal: Analytical Chemistry
PubMed ID: 39096242
Doi: 10.1021/acs.analchem.4c02270
Products & Services: Peptide Synthesis   
Reversibly photoswitchable protein assemblies with collagen affinity for in vivo photoacoustic imaging of tumors
Authors: Shuai Chen , Kaixin Li , Xin Chen , Shan Lei , Jing Lin , Peng Huang
Journal: Science Advances
PubMed ID: 39213344
Doi: 10.1126/sciadv.adn8274
Products & Services: Codon Optimization   
Identification of endothelial protein C receptor as a novel druggable agonistic target for reendothelialization promotion and thrombosis prevention of eluting stent
Authors: Jing Chen , Changyi Zhou , Weilun Fang , Jiasheng Yin , Jian Shi , Junbo Ge , Li Shen , Shi-Ming Liu , Shao-Jun Liu
Journal: Bioactive Materials
Doi: doi.org/10.1016/j.bioactmat.2024.07.028
Products & Services: Peptide Synthesis   
Lytic transglycosylase Slt of Pseudomonas aeruginosa as a periplasmic hub protein
Authors: Luis F Avila-Cobian, Stefania De Benedetti, Hidekazu Hoshino, Van T Nguyen, Amr M El-Araby, Safaa Sader, Daniel D Hu, Sara L Cole, Choon Kim, Jed F Fisher, Matthew M Champion, Shahriar Mobashery
Journal: Protein Sci
PubMed ID: 38864725
Doi: 10.1002/pro.5038
Products & Services: Molecular Biology Reagents   
The strongest protein binder is surprisingly labile
Authors: Alba Fernandez-Calvo, Antonio Reifs, Laura Saa, Aitziber L Cortajarena, David De Sancho, Raul Perez-Jimenez
Journal: Protein Sci
PubMed ID: 38864696
Doi: 10.1002/pro.5030
Products & Services: Molecular Biology Reagents   
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