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Expanding the genetic toolbox for the obligate human pathogen
Authors: Nina Lautenschläger, Katja Schmidt, Carolin Schiffer, Thomas F Wulff, Karin Hahnke, Knut Finstermeier, Moïse Mansour, Alexander K W Elsholz, Emmanuelle Charpentier
Journal: Front Bioeng Biotechnol
PubMed ID: 38911550
Doi: 10.3389/fbioe.2024.1395659
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Novel chymotrypsin C (CTRC) variants from real-world genetic testing of pediatric chronic pancreatitis cases
Authors: Regina Stefanovics, Máté Sándor, Alexandra Demcsák, Gergő Berke, Balázs Csaba Németh, Wenying Zhang, Maisam Abu-El-Haija, Miklós Sahin-Tóth
Journal: Pancreatology
PubMed ID: 38876922
Doi: 10.1016/j.pan.2024.06.003
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GhMPK9-GhRAF39_1-GhWRKY40a Regulates the GhERF1b- and GhABF2-Mediated Pathways to Increase Cotton Disease Resistance
Authors: Xinyue Mi, Weixi Li, Chuan Chen, Huijuan Xu, Guilin Wang, Xuanxiang Jin, Dayong Zhang, Wangzhen Guo
Journal: Adv Sci (Weinh)
PubMed ID: 38845189
Doi: 10.1002/advs.202404400
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A Unique mRNA Vaccine Elicits Protective Efficacy against the SARS-CoV-2 Omicron Variant and SARS-CoV
Authors: Xiaoqing Guan, Abhishek K Verma, Gang Wang, Abhijeet Roy, Stanley Perlman, Lanying Du
Journal: Vaccines (Basel)
PubMed ID: 38932334
Doi: 10.3390/vaccines12060605
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A novel xylanase from a myxobacterium triggers a plant immune response in Nicotiana benthamiana
Authors: Yuqiang Zhao, Kun Yang, Yanxin Wang, Xu Li, Chengyao Xia, Yan Huang, Zhoukun Li, Cancan Zhu, Zhongli Cui, Xianfeng Ye
Journal: Mol Plant Pathol
PubMed ID: 38924248
Doi: 10.1111/mpp.13488
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The Interplay of Acetylation and Ubiquitination Controls PRMT1 Homeostasis
Authors: Mohd Altaf Najar, Jenna N Beyer, Callie E W Crawford, George M Burslem
Journal: biorxiv
PubMed ID: 38948822
Doi: 10.1101/2024.06.18.599616
Products & Services: Molecular Biology Reagents   
Bioorthogonal non-canonical amino acid tagging to track transplanted human induced pluripotent stem cell-specific proteome
Authors: Divya Sridharan, Julie A Dougherty, Uzair Ahmed, Shridhar K Sanghvi, Syed Baseeruddin Alvi, Ki Ho Park, Helena Islam, Sue E Knoblaugh, Harpreet Singh, Elizabeth D Kirby, Mahmood Khan
Journal: Stem Cell Res Ther
PubMed ID: 38926849
Doi: 10.1186/s13287-024-03792-3
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A self-healing multispectral transparent adhesive peptide glass
Authors: Gal Finkelstein-Zuta, Zohar A Arnon, Thangavel Vijayakanth, Or Messer, Orr Simon Lusky, Avital Wagner, Galit Zilberman, Ruth Aizen, Lior Michaeli, Sigal Rencus-Lazar, Sharon Gilead, Sudha Shankar, Mariela Jorgelina Pavan, Dor Aaron Goldstein, Shira Kutchinsky, Tal Ellenbogen, Benjamin A Palmer, Amir Goldbourt, Maxim Sokol, Ehud Gazit
Journal: Nature
PubMed ID: 38867128
Doi: 10.1038/s41586-024-07408-x
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CD70-specific CAR NK cells expressing IL-15 for the treatment of CD19-negative B-cell malignancy
Authors: Shanshan Guo, Wen Lei, Xueli Jin, Hui Liu, James Q Wang, Wenhai Deng, Wenbin Qian
Journal: Blood Adv
PubMed ID: 38564778
Doi: 10.1182/bloodadvances.2023012202
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Metagenomic exploration of cold-active enzymes for detergent applications: Characterization of a novel, cold-active and alkali-stable GH8 endoglucanase from ikaite columns in SW Greenland
Authors: Bianca Oliva, Athanasios Zervas, Peter Stougaard, Peter Westh, Mariane Schmidt Thøgersen
Journal: Microb Biotechnol
PubMed ID: 38829370
Doi: 10.1111/1751-7915.14466
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Comparative Analysis of Orthosteric and Allosteric GLP-1R Agonists' Effects on Insulin Secretion from Healthy, Diabetic, and Recovered INS-1E Pancreatic Beta Cells
Authors: Joshua Reed, Victoria Higginbotham, Stephen Bain, Venkateswarlu Kanamarlapudi
Journal: Int J Mol Sci
PubMed ID: 38928038
Doi: 10.3390/ijms25126331
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Molecular and structural basis of an ATPase-nuclease dual-enzyme anti-phage defense complex
Authors: Qiyin An, Yong Wang, Zhenhua Tian, Jie Han, Jinyue Li, Fumeng Liao, Feiyang Yu, Haiyan Zhao, Yancheng Wen, Heng Zhang & Zengqin Deng
Journal: Cell Research
PubMed ID: 38834762
Doi: 10.1038/s41422-024-00981-w
XIST dampens X chromosome activity in a SPEN-dependent manner during early human development
Authors: Charbel Alfeghaly, Gaël Castel, Emmanuel Cazottes, Madeleine Moscatelli, Eva Moinard, Miguel Casanova, Juliette Boni, Kasturi Mahadik, Jenna Lammers, Thomas Freour, Louis Chauviere, Carla Piqueras, Ruben Boers, Joachim Boers, Joost Gribnau, Laurent David, Jean-François Ouimette & Claire Rougeulle
Journal: Nat Struct Mol Biol
PubMed ID: 38834912
Doi: 10.1038/s41594-024-01325-3
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Characterization and regulation of cell cycle-independent noncanonical gene targeting
Authors: Shinta Saito & Noritaka Adachi
Journal: Nature Communications
PubMed ID: 38890315
Doi: 10.1038/s41467-024-49385-9.
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Protein engineering enables a soakable crystal form of human CDK7 primed for high-throughput crystallography and structure-based drug design
Authors: Manjeet Mukherjee, Philip J Day, Duncan Laverty, Juan A Bueren-Calabuig, Andrew J Woodhead, Charlotte Griffiths-Jones, Steve Hiscock, Charlotte East, Susan Boyd, Marc O'Reilly
Journal: Structure
PubMed ID: 38870939
Doi: 10.1016/j.str.2024.05.011
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Dual-Omics Approach Unveils Novel Perspective on the Quality Control of Genetically Engineered Exosomes
Authors: Christopher Olson, Konstantin Ivanov, Darin Boyes, David Bengford, Joy Ku, Renceh Flojo, Pengyang Zhang, Biao Lu
Journal: Pharmaceutics
PubMed ID: 38931944
Doi: 10.3390/pharmaceutics16060824
Products & Services: Molecular Biology Reagents   
Integrated pathway mining and selection of an artificial CYP79-mediated bypass to improve benzylisoquinoline alkaloid biosynthesis
Authors: Musashi Takenaka, Kouhei Kamasaka, Kim Daryong, Keiko Tsuchikane, Seiha Miyazawa, Saeko Fujihana, Yoshimi Hori, Christopher J Vavricka, Akira Hosoyama, Hiroko Kawasaki, Tomokazu Shirai, Michihiro Araki, Akira Nakagawa, Hiromichi Minami, Akihiko Kondo, Tomohisa Hasunuma
Journal: Microb Cell Fact
PubMed ID: 38879464
Doi: 10.1186/s12934-024-02453-7
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Designing monomeric IFNγ: the significance of domain-swapped dimer structure in IFNγ immune responses
Authors: Yota Goto, Takamitsu Miyafusa, Shinya Honda
Journal: J Biol Chem
PubMed ID: 38879015
Doi: 10.1016/j.jbc.2024.107464
Products & Services: Molecular Biology Reagents   
Identification of potential crucial cuproptosis-related genes in myocardial ischemia-reperfusion injury through the bioinformatic analysis
Authors: Rong Huang, Rongfeng Xu, Rui Zhang, Wenjie Zuo, Zhenjun Ji, Zaixiao Tao, Yongjun Li, Genshan Ma
Journal: Clinics (Sao Paulo)
PubMed ID: 38901133
Doi: 10.1016/j.clinsp.2024.100410
Products & Services: Gene Synthesis   
SARS-CoV-2 Humoral and Cellular Immune Responses in People Living with HIV
Authors: Simona Ruta, Corneliu Petru Popescu, Lilia Matei, Camelia Grancea, Adrian Marius Paun, Cristiana Oprea, Camelia Sultana
Journal: Vaccines (Basel)
PubMed ID: 38932392
Doi: 10.3390/vaccines12060663
Products & Services: Molecular Biology Reagents   
PDZ2-conjugated-PLGA nanoparticles are tiny heroes in the battle against SARS-CoV-2
Authors: Noah Giacon, Ettore Lo Cascio, Valeria Pennacchietti, Flavio De Maio, Giulia Santarelli, Diego Sibilia, Federica Tiberio, Maurizio Sanguinetti, Wanda Lattanzi, Angelo Toto, Alessandro Arcovito
Journal: Sci Rep
PubMed ID: 38844490
Doi: 10.1038/s41598-024-63239-w
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Inefficient recruitment of DDX39B impedes pre-spliceosome assembly on introns
Authors: Chloe K Nagasawa, Aaron O Bailey, William K Russell, Mariano A Garcia-Blanco
Journal: RNA
PubMed ID: 38575347
Doi: 10.1261/rna.079933.123
Discovery of Monovalent Direct Degraders of BRD4 That Act Via the Recruitment of DCAF11
Authors: Gregory S Parker, Julia I Toth, Sarah Fish, Gabrielle A Blanco, Taylor Kampert, Xiaoming Li, Linette Yang, Craig R Stumpf, Kenneth Steadman, Aleksandar Jamborcic, Stephen Chien, Elizabeth Daniele, Alejandro Dearie, Geoffray Leriche, Simon Bailey, Peggy A Thompson
Journal: Mol Cancer Ther
PubMed ID: 38907538
Doi: 10.1158/1535-7163.MCT-24-0219
Molecular Mechanism of WWOX Inhibiting the Development of Esophageal Cancer by Inhibiting Hippo Signaling Pathway
Authors: Zihan Chen, Jingyu Sun, Lili Zhang, Yanglin Sun, Qingqing Ni, Hongkun Zhu, Miao Hui, Longzhen Zhang, Qiang Wang
Journal: Biochem Genet
PubMed ID: 38902482
Doi: 10.1007/s10528-024-10856-9
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Patients taking benralizumab, dupilumab, or mepolizumab have lower postvaccination SARS-CoV-2 immunity
Authors: Martin C Runnstrom, Pedro A Lamothe, Caterina E Faliti, Narayanaiah Cheedarla, Alberto Moreno, Mehul S Suthar, Rishika Nahata, Mayuran Ravindran, Natalie S Haddad, Andrea Morrison-Porter, Hannah Quehl, Richard P Ramonell, Matthew Woodruff, Fabliha Anam, Rebeca Zhang, Colin Swenson, Carmen Polito, Wendy Neveu, Rahulkumar Patel, Natalia Smirnova, Doan C Nguyen, Caroline Kim, Ian Hentenaar, Shuya Kyu, Sabeena Usman, Thuy Ngo, Zhenxing Guo, Hao Wu, John L Daiss, Jiwon Park, Kelly E Manning, Bursha Wali, Madison L Ellis, Sunita Sharma, Fernando Holguin, Suneethamma Cheedarla, Andrew S Neish, John D Roback, Ignacio Sanz, F Eun-Hyung Lee
Journal: J Allergy Clin Immunol
PubMed ID: 38878020
Doi: 10.1016/j.jaci.2024.03.029
Integration of Image Pattern Recognition and Photon Sensor for Analyzing Cytokine Gene Expression Using πCode MicroDisc
Authors: On-Anong Juntit, Kanokporn Sornsuwan, Umpa Yasamut, Chatchai Tayapiwatana
Journal: Biosensors (Basel)
PubMed ID: 38920610
Doi: 10.3390/bios14060306
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High sugar diet-induced fatty acid oxidation potentiates cytokine-dependent cardiac ECM remodeling
Authors: Jayati Gera, Dheeraj Kumar, Gunjan Chauhan, Adarsh Choudhary, Lavi Rani, Lolitika Mandal, Sudip Mandal
Journal: J Cell Biol
PubMed ID: 38916917
Doi: 10.1083/jcb.202306087
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Injectable Self-Healing Antibacterial Hydrogels with Tailored Functions by Loading Peptide Nanofiber-Biomimetic Silver Nanoparticles
Authors: Mingze Zhang, Guanghui Gu, Youyin Xu, Xin Luan, Jianyu Liu, Peng He, Gang Wei
Journal: Macromol Rapid Commun
PubMed ID: 38923127
Doi: 10.1002/marc.202400173
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A peptide derived from sorting nexin 1 inhibits HPV16 entry, retrograde trafficking, and L2 membrane spanning
Authors: Shuaizhi Li, Zachary L Williamson, Matthew A Christofferson, Advait Jeevanandam, Samuel K Campos
Journal: Tumour Virus Res
PubMed ID: 38909779
Doi: 10.1016/j.tvr.2024.200287
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Genetically Programmed Temperature-Responsive Barnacle-Derived Protein with an Enhanced Adhesion Ability
Authors: Yuanxing Shi, Yun Xu, Longyu Zhang, Yunjun Yan, Jinyong Yan
Journal: ACS Appl Bio Mater
PubMed ID: 38926913
Doi: 10.1021/acsabm.4c00455
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Evaluating the antibody response elicited by diverse HIV envelope immunogens in the African green monkey (Vervet) model
Authors: Thandeka Moyo-Gwete, Frances Ayres, Nonkululeko B Mzindle, Zanele Makhado, Nelia P Manamela, Simone I Richardson, Dale Kitchin, Strauss van Graan, Joritha van Heerden, Nishal Parbhoo, Gerald K Chege, Penny L Moore
Journal: Sci Rep
PubMed ID: 38858452
Doi: 10.1038/s41598-024-63703-7
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CEPs suppress auxin signaling but promote cytokinin signaling to inhibit root growth in Arabidopsis
Authors: Yuwen Zhang, Xingliang Duan, Zhen Wang, Yuanda Lv, Weicong Qi, Lun Li, Le Luo, Wei Xuan
Journal: Biochem Biophys Res Commun .
PubMed ID: 38626621
Doi: 10.1016/j.bbrc.2024.149934
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A growth selection system for sucrose synthases (SuSy): design and test
Authors: Gonzalo N Bidart, Se Hyeuk, Tobias Benedikt Alter, Lei Yang, Ditte Hededam Welner
Journal: AMB Express
PubMed ID: 38865019
Doi: 10.1186/s13568-024-01727-y
Products & Services: Molecular Biology Reagents   
BRET-based biosensors for SARS-CoV-2 oligonucleotide detection
Authors: Asfia Sultana, Anupriya M Geethakumari, Zeyaul Islam, Prasanna R Kolatkar, Kabir H Biswas
Journal: Front Bioeng Biotechnol
PubMed ID: 38887615
Doi: 10.3389/fbioe.2024.1353479
Repeat controlled human Plasmodium falciparum infections delay bloodstream patency and reduce symptoms
Authors: Patricia Ferrer, Andrea A Berry, Allison N Bucsan, Surendra K Prajapati, Karthik Krishnan, Michelle C Barbeau, David M Rickert, Sandra Mendoza Guerrero, Miho Usui, Yonas Abebe, Asha Patil, Sumana Chakravarty, Peter F Billingsley, Faith Pa'ahana-Brown, Kathy Strauss, Biraj Shrestha, Effie Nomicos, Gregory A Deye, B Kim Lee Sim, Stephen L Hoffman, Kim C Williamson, Kirsten E Lyke
Journal: Nat Commun
PubMed ID: 38890271
Doi: 10.1038/s41467-024-49041-2
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The role of shear forces in primary and secondary nucleation of amyloid fibrils
Authors: Emil Axell, Jing Hu, Max Lindberg, Alexander J Dear, Lei Ortigosa-Pascual, Ewa A Andrzejewska, Greta Šneiderienė, Dev Thacker, Tuomas P J Knowles, Emma Sparr, Sara Linse
Journal: Proc Natl Acad Sci U S A
PubMed ID: 38875148
Doi: 10.1073/pnas.2322572121
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The generation of stable transgenic lines in the human-infective nematode Strongyloides stercoralis
Authors: Ruhi Patel, Astra S Bryant, Michelle L Castelletto, Breanna Walsh, Damia Akimori, Elissa A Hallem
Journal: G3 (Bethesda)
PubMed ID: 38839055
Doi: 10.1093/g3journal/jkae122
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The BICD2 dynein cargo adaptor binds to the HPV16 L2 capsid protein and promotes HPV infection
Authors: Kaitlyn Speckhart, Jeongjoon Choi, Daniel DiMaio, Billy Tsai
Journal: PLoS Pathog
PubMed ID: 38829892
Doi: 10.1371/journal.ppat.1012289
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The annotation of has been concealed by its protein-coding pseudogene
Authors: Emil K Gustavsson, Siddharth Sethi, Yujing Gao, Jonathan W Brenton, Sonia García-Ruiz, David Zhang, Raquel Garza, Regina H Reynolds, James R Evans, Zhongbo Chen, Melissa Grant-Peters, Hannah Macpherson, Kylie Montgomery, Rhys Dore, Anna I Wernick, Charles Arber, Selina Wray, Sonia Gandhi, Julian Esselborn, Cornelis Blauwendraat, Christopher H Douse, Anita Adami, Diahann A M Atacho, Antonina Kouli, Annelies Quaegebeur, Roger A Barker, Elisabet Englund, Frances Platt, Johan Jakobsson, Nicholas W Wood, Henry Houlden, Harpreet Saini, Carla F Bento, John Hardy, Mina Ryten
Journal: Sci Adv
PubMed ID: 38924406
Doi: 10.1126/sciadv.adk1296
Divergent humoral responses between males and females against 24 kDa excretory-secretory protein of Haemonchus contortus and influence of ovine β-globin polymorphism
Authors: Cintia Hiromi Okino, Simone Cristina Méo Niciura, Alessandro Pelegrine Minho, Sérgio Novita Esteves, Gláucia Roberta Melito, Hélio José Montassier, Ana Carolina de Souza Chagas
Journal: Dev Comp Immunol
PubMed ID: 38901502
Doi: 10.1016/j.dci.2024.105216
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Arabidopsis pollen prolyl-hydroxylases P4H4/6 are relevant for correct hydroxylation and secretion of LRX11 in pollen tubes
Authors: Ana R Sede, Diego L Wengier, Cecilia Borassi, Martiniano Ricardi, Sofía C Somoza, Rafael Aguiló, José M Estevez, Jorge P Muschietti
Journal: J Exp Bot
PubMed ID: 38877792
Doi: 10.1093/jxb/erae269
Functional characterization of polyphenol oxidase OfPPO2 supports its involvement in parallel biosynthetic pathways of acteoside
Authors: Yating Liu, Xiaoyang Han, Mengya Zhao, Lan Liu, Zixin Deng, Qiu Zhao, Yi Yu
Journal: Plant J
PubMed ID: 38872484
Doi: 10.1111/tpj.16807
Ancient nitrogenases are ATP dependent
Authors: Derek F Harris, Holly R Rucker, Amanda K Garcia, Zhi-Yong Yang, Scott D Chang, Hannah Feinsilber, Betül Kaçar, Lance C Seefeldt
Journal: MBio
PubMed ID: 38869277
Doi: 10.1128/mbio.01271-24
MiR-23b-3p alleviates Sjögren's syndrome by targeting SOX6 and inhibiting the NF-κB signaling
Authors: Yan Cai, Yi Zhang, Sihan Wang, E Changyong
Journal: Mol Immunol
PubMed ID: 38901181
Doi: 10.1016/j.molimm.2024.06.002
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Characteristics of Retinal Vascular Degeneration and the Expression of Vessel-Related Claudin Proteins in Retinal Degeneration Mouse
Authors: Aoxiang Wang, Jinxi Zhou, Yiwen Hong, Yamei Cui, Yishen Wang, Jianying Pan, Yue Wu, Yan Luo
Journal: Ophthalmic Res
PubMed ID: 38857592
Doi: 10.1159/000539605
Celastrol reduces lung inflammation induced by multiwalled carbon nanotubes in mice NF-κb-signaling pathway
Authors: Tao-Lin Qing, Xuan-Yao Jiang, Jin-Feng Li, Qi Shen, Xin-Yi Zhao, Li-Jun Ren, Xiao-Yu Dai, Ji-Qian-Zhu Zhang, Wen-Jing Shi, Xiao-Fang Zhang, Bin Zhang, Lang Yan, Ji-Kuai Chen, Jiang-Bo Zhu
Journal: Inhal Toxicol
PubMed ID: 38836332
Doi: 10.1080/08958378.2024.2351098
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Comparison of the performance of SAG2, GRA6, and GRA7 for serological diagnosis of infection in cats
Authors: Serges Sabukunze, Haorong Gu, Lin Zhao, Honglin Jia, Huanping Guo
Journal: Front Vet Sci
PubMed ID: 38898997
Doi: 10.3389/fvets.2024.1423581
A full-length glycoprotein mRNA vaccine confers complete protection against severe fever with thrombocytopenia syndrome virus, with broad-spectrum protective effects against bandaviruses
Authors: Jia Lu, Jun Liu, Yan Wu, Xiaoxue He, Xiao Gao, Xinlan Chen, Shaoyi Chen, Xuerui Zhu, Yucai Peng, Gengfu Xiao, Xiaoyan Pan
Journal: J Virol
PubMed ID: 38829138
Doi: 10.1128/jvi.00769-24
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Sequence and structure analyses of lytic polysaccharide monooxygenases mined from metagenomic DNA of humus samples around white-rot fungi in Cuc Phuong tropical forest, Vietnam
Authors: Nam-Hai Truong, Thi-Thu-Hong Le, Hong-Duong Nguyen, Hong-Thanh Nguyen, Trong-Khoa Dao, Thi-Minh-Nguyet Tran, Huyen-Linh Tran, Dinh-Trong Nguyen, Thi-Quy Nguyen, Thi-Hong-Thao Phan, Thi-Huyen Do, Ngoc-Han Phan, Thi-Cam-Nhung Ngo, Van-Van Vu
Journal: PeerJ
PubMed ID: 38938609
Doi: 10.7717/peerj.17553
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Hepatitis C virus NS5A and core protein induce fibrosis-related genes regulation on Huh7 cells through activation of LX2 cells
Authors: Tania G Heredia-Torres, Veronica Alvarado-Martínez, Ana R Rincon-Sanchez, Sonia A Lozano-Sepulveda, Kame Galan-Huerta, Daniel Arellanos-Soto, Ana M Rivas-Estilla
Journal: Ann Hepatol
PubMed ID: 38852781
Doi: 10.1016/j.aohep.2024.101517
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