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Engineered ipilimumab variants that bind human and mouse CTLA-4
Authors: Brett Robison 1, S J Diong 1, Anusha Kumar 1, Thomas M Moon , Olin Chang , Bryant Chau , Christine Bee , Ishita Barman , Arvind Rajpal , Alan J Korman , Sean West , Pavel Strop , Peter S Lee
Journal: MAbs
PubMed ID: 39849917
Doi: 10.1080/19420862.2025.2451296
Products & Services: Combinatorial DNA Libraries   
Optimization of Multiple Combinations of Early Secretion Pathways to Enhance Extracellular Protein Secretion in Komagataella phaffii
Authors: Hai Xu, Shijie Wang, Kang Li, Zhonghu Bai, Yankun Yang
Journal: JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
PubMed ID: 40616507
Doi: doi.org/10.1021/acs.jafc.5c03402
Products & Services: Gene Synthesis   
Single-cell RNA sequencing and PANDORA-seq reveal the pivotal role of piRNA in heat stress-induced testicular injury
Authors: Mailin Gan, Jianfeng Ma, Yuhang Lei, Yiting Yang, Yuheng Pan, Shuang Wu, Siyu Chen, Jiaxin Li, Linyuan Shen, Li Zhu
Journal: International Journal of Biological Macromolecules
PubMed ID: 40609925
Doi: 10.1016/j.ijbiomac.2025.145674
Co‑treatment with triptolide and RSL3 induces hepatocellular carcinoma cell apoptosis and ferroptosis
Authors: Weixia Liu , Guodi Wu , Jing Wang , Shanshan Wu , Zhi Chen
Journal: Molecular Medicine Reports
PubMed ID: 40376993
Doi: 10.3892/mmr.2025.13567
Activation of mechanosensitive ion channel Piezo1 linking metabolic reprogramming and pro-inflammatory responses in hepatocellular carcinoma
Authors: Juanfen Mo, YuXuan Zhang, Chenxi Cao, WeiLi Zheng, Li Zheng, Xiaoguang Wang, Shiyue Wang, Jiayuan Wu, Yi Bao
Journal: Cell Communication and Signaling
PubMed ID: 40514668
Doi: 10.1186/s12964-025-02289-7
Topical delivery of a human single-domain antibody targeting IL-33 to inhibit mucosal inflammation
Authors: Keke Huang, Yuqing Wu, Yu Kong, Qingyuan Xu, Mingwei Lv, Yirou Zhang, Yiteng Lu, Quanxiao Li, Cheng Li, Wenping Song, Xiaoyi Zhu, Zhenlin Yang, Changchang Xin, Xujiao Zhou, Tianlei Ying, Yanling Wu, Jiaxu Hong
Journal: Cellular & Molecular Immunology
PubMed ID: 40500403
Doi: 10.1038/s41423-025-01305-7
Rice E3 ubiquitin ligase BLAST AND BTH-INDUCED 1 targets jasmonic acid signaling co-repressors to release Myelocytomatosis protein 2 for modulating immune responses against blast fungus
Authors: Yan Bi , Yuqing Yan , Hui Wang , Leeza Tariq , Dayong Li , Fengming Song
Journal: International Journal of Biological Macromolecules
PubMed ID: 40543771
Doi: doi.org/10.1016/j.ijbiomac.2025.145363
Products & Services: Catalog Peptides   
LEDGF Binds H3R17me2a Promoting De Novo Nucleotide Biosynthesis in SETD2 Mutant Clear Cell Renal Cell Carcinoma
Authors: Yuwei Zhang, Yuhua Zhou, Yuezhou Zhang, Jing Lv, Yang Shen, Dong Zhang, Bo Liu, Wei Zhao, Junyi Ju, Qingyi Zhu, Ke Wang, Ninghan Feng
Journal: Advanced Science
Doi: doi.org/10.1002/advs.202416809
Products & Services: Peptide Modifications   
An all-silk-based functional system promotes tendon regeneration by regulating the cell fate of TSPCs in an inflammatory microenvironment
Authors: Qingyun Mo, Haotian Zheng, Chuanquan Liu, Yuzhi Sun, Zhicheng Cao, Renwang Sheng, Yanan Zhang, Mingyue Wang, Baian Kuang, Ludvig J Backman, Jiaxiang Li, Wei Zhang, Jialin Chen
Journal: Acta Biomaterialia
PubMed ID: 40409996
Doi: 10.1016/j.actbio.2025.05.040
Products & Services: Recombinant Proteins   
AIDS patients suffer higher risk of advanced knee osteoarthritis progression due to lopinavir-induced Zmpste24 inhibition
Authors: Keyu Kong, Li Liu, Renfang Zhang, Yongyun Chang, Yueming Shao, Chen Zhao, Hua Qiao, Minghao Jin, Xuzhuo Chen, Wentao Shi, Xinru Wu, Wenxuan Fan, Yuehao Hu, Kewei Rong, Pu Zhang, Baixing Li, Jingwei Zhang, Peixiang Ma, Xiaoling Zhang, Huiwu Li, Zanjing Zhai
Journal: Bone Research
PubMed ID: 40461512
Doi: 10.1038/s41413-025-00431-2
Products & Services: Recombinant Proteins   
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