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De novo fatty acid synthesis at the mitotic exit is required to complete cellular division.

Cell Cycle.. 2014-03;  13(5):859-868
Scaglia N, Tyekucheva S, Zadra G, Photopoulos C, Loda M. Department of Medical Oncology; Dana-Farber Cancer Institute; Harvard Medical School; Boston, MA USA.
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Although the regulation of the cell cycle has been extensively studied, much less is known about its coordination with the cellular metabolism. Using mass spectrometry we found that lysophospholipid levels decreased drastically from G 2/M to G 1 phase, while de novo phosphatidylcholine synthesis, the main phospholipid in mammalian cells, increased, suggesting that enhanced membrane production was concomitant to a decrease in its turnover. In addition, fatty acid synthesis and incorporation into membranes was increased upon cell division. The rate-limiting reaction for de novo fatty acid synthesis is catalyzed by acetyl-CoA carboxylase. As expected, its inhibiting phosphorylation decreased prior to cytokinesis i... More


AMPK, C75; cell cycle; cell cycle arrest; de novo lipogenesis; fatty acid; lysophospholipid; metabolome; phospholipid