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Polyoma Small T Antigen Interacts with YES-Associated Protein (YAP) to Regulate Cell Survival and Differentiation.

J Virol.. 2014-08; 
Hwang JH, Pores Fernando AT, Faure N, Andrabi S, Hahn WC, Schaffhausen BS, Roberts TM. Departments of Cancer Biology and Biological Chemistry and Molecular Pharmacology, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02215.
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Murine polyomavirus small T antigen (PyST) regulates cell cycle, cell survival, apoptosis, differentiation and cooperates with middle T antigen (MT) to transform primary cells in vitro and in vivo. Like all polyoma virus T antigens, PyST functions largely via its interactions with host cell proteins. Here we show that PyST binds both Yes-associated proteins YAP1 and YAP2, integral parts of the Hippo signaling pathway, which is a subject of increasing interest in human cancer. The transcription factor TEAD, which is a known target of YAP, is also found in PyST complexes. PyST enhanced YAP association with protein phosphatase 2A (PP2A) leading to decreased YAP phosphorylation. PyST increased YAP levels by decreas... More