Green synthesis palladium nanoparticles mediated by white tea () extract with antioxidant， antibacterial， and antiproliferative activities toward the human leukemia (MOLT-4) cell line.

Among nanoparticles used for medical applications， palladium nanoparticles (PdNPs) are among the least investigated. This study was undertaken to develop PdNPs by green synthesis using white tea (W.tea; ) extract to produce the [email protected] NPs. The [email protected] NPs were characterized by UV-vis spectroscopy and X-ray diffractometry， and evaluated with transmission electron microscopy (TEM) and scanning electron microscopy (SEM). The [email protected] NPs were spherical (size 6-18 nm) and contained phenols and flavonoids acquired from the W.tea extract. [email protected] NPs has good 1-diphenyl-2-picrylhydrazyl (DPPH)， OH， and NO-scavenging properties as well as antibacterial effects toward and . MTT assay showed that [email protected] NPs (IC =0.006 μM) were more antiproliferative toward the human leukemia (MOLT-4) cells than the W.tea extract (IC =0.894 μM)， doxorubicin (IC =2.133 μM)， or cisplatin (IC =0.013 μM)， whereas they were relatively innocuous for normal human fibroblast (HDF-a) cells. The anticancer cell effects of [email protected] NPs are mediated through the induction of apoptosis and G2/M cell-cycle arrest.