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Citations Search |
- Ultrasound Med Biol 2020;
Development of a Translatable Ultrasound Molecular Imaging Agent for Inflammation.
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… 2 μL was added to a nitrocellulose square. The nitrocellulose membrane was dried for 1 h at RT, then blocked in 0.5% Quickblock (GenScript, Piscataway, NJ, USA) for 1 h at RT. The membrane was rinsed three times in TBST … | |
AbstractThis study details the development, characterization and non-clinical efficacy of an ultrasound molecular imaging agent intended for molecular imaging of P-selectin in humans. A targeting ligand based on a recently discovered human selectin ligand was manufactured as fusion protein, and activity for human and mouse P- and E-selectin was evaluated by functional immunoassay. The targeting ligand was covalently conjugated to a lipophilic anchor inserted into a phospholipid microbubble shell. Three lots of the targeted microbubble drug product, TS-07-009, were produced, and assays for size distribution, zeta potential and morphology were established. The suitability of TS-07-009 as a molecular imaging agent was eva... More KeywordsMicrobubble; Molecular imaging; P-selectin; Perfluorocarbon; TIM-1; Ultrasound imaging Most Popular Services
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