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Development of a Translatable Ultrasound Molecular Imaging Agent for Inflammation.

Ultrasound Med Biol. 2020; 
Luong A, Smith D, Tai CH, Cotter B, Luo C, Strachan M, DeMaria A, Rychak JJ.
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Abstract

This study details the development, characterization and non-clinical efficacy of an ultrasound molecular imaging agent intended for molecular imaging of P-selectin in humans. A targeting ligand based on a recently discovered human selectin ligand was manufactured as fusion protein, and activity for human and mouse P- and E-selectin was evaluated by functional immunoassay. The targeting ligand was covalently conjugated to a lipophilic anchor inserted into a phospholipid microbubble shell. Three lots of the targeted microbubble drug product, TS-07-009, were produced, and assays for size distribution, zeta potential and morphology were established. The suitability of TS-07-009 as a molecular imaging agent was eva... More

Keywords

Microbubble; Molecular imaging; P-selectin; Perfluorocarbon; TIM-1; Ultrasound imaging