For each citation that was shared on social media (LinkedIn, Facebook, or Twitter) with the “@GenScript” tag, the author will be rewarded with a $10 Amazon gift card or 2,000 GS points.

Inclusion of PD-L1 into a recombinant profilin antigen enhances immunity against Babesia microti in a murine model

Ticks and Tick-borne Diseases. 2020-04; 
NanaWei,JinmiaoLu,HaiyanGong,ZhengmaoXu,HoushuangZhang,LiCui,JinlinZhou,ZhibingLin
Products/Services Used Details Operation
Cellular Analysis Detoxi-Gel™ endotoxin-removing columns (Thermo Scientific™, USA) and the Limulus amebocyte lysate test (LAL, GenScript, China) were used for endotoxin removal and endotoxin levels monitoring, respectively. Get A Quote

Abstract

Pathogens and cancer cells employ the programmed cell death-Ligand 1 (PD-L1)/ programmed cell death-1 (PD-1) signaling pathway to inhibit the immune response. Hence, blockade of PD-L1/PD-1 recognition through monoclonal antibodies enhances the immune response. Antibodies that block PD-L1 and PD-1 binding have been used for the prevention and therapy of human pathogenic diseases, but have not yet been evaluated for the treatment of infectious diseases of livestock. In the present study, a recombinant vaccine named PROF-PDL1E, was designed comprising the Babesia microti-derived vaccine candidate profilin and the host PD-L1 protein, and its effect on immunization against murine B. microti infection was evaluate... More

Keywords

VaccineSelf-antigenPD-L1Babesia microtiImmune checkpoint