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Tissue-Engineered Interlocking Scaffold Blocks for the Regeneration of Bone

JOM. 2020; 
Krishna Kundu, Dinesh R. Katti & Kalpana S. Katti
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Biochemicals … Following this, samples were immersed in 100% ethanol for 24 h for sterilization followed by washing with PBS BMP 2 (Genscript) and BMP 7 (Biovision) solutions were prepared by dissolving in cell culture grade water at a concentration of 1 μg/ml … Get A Quote

Abstract

The duration of time over which bone growth is initiated in large bone defects using tissue-engineered scaffolds is still too long to be of practical relevance. Here, we report a unique design of mechanically stable interlocking blocks wherein the large defect shape is filled using interlocking scaffold blocks coated with bone morphogenic proteins (BMP-2 and BMP-7). The nanocomposite scaffold blocks are made using polycaprolactone and amino acid-modified nanoclays intercalated with mineralized hydroxyapatite. On seeding with human mesenchymal stem cells and osteoblasts, BMP-coated scaffolds showed higher ECM formation. Also, when assembled, accelerated tissue growth was observed compared with the similar-sized ... More

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