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- Commun Biol 2020-12;
β-arrestin mediates communication between plasma membrane and intracellular GPCRs to regulate signaling
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… f Initial antibody block reduced relative CXCR4 expression and basal UMB2 detection. g … Dynasore 324410 Sigma 100 µM MTA D5011 Thermo Fisher 200 µM Antibodies ms-FLAG-647 A01811-100 Genscript 1:1000 (FC/IF) rb-MYC A190-105A Bethyl Laboratories 1:5000 (WB) … | |
AbstractIt has become increasingly apparent that G protein-coupled receptor (GPCR) localization is a master regulator of cell signaling. However, the molecular mechanisms involved in this process are not well understood. To date, observations of intracellular GPCR activation can be organized into two categories: a dependence on OCT3 cationic channel-permeable ligands or the necessity of endocytic trafficking. Using CXC chemokine receptor 4 (CXCR4) as a model, we identified a third mechanism of intracellular GPCR signaling. We show that independent of membrane permeable ligands and endocytosis, upon stimulation, plasma membrane and internal pools of CXCR4 are post-translationally modified and collectively regulate EGR1 ... More KeywordsMost Popular Services |