For each citation that was shared on social media (LinkedIn, Facebook, or Twitter) with the “@GenScript” tag, the author will be rewarded with a $10 Amazon gift card or 2,000 GS points.

Engineered Bacteriophage T7 as a Potent Anticancer Agent

Front Microbiol. 2020; 
Yoon Jung Hwang, Heejoon Myung
Products/Services Used Details Operation
Molecular Biology Reagents … Group 5 mice were treated with 1 × 10 9 PFU of pep42-displaying bacteriophage T7 and 1 ng of GM-CSF (catalogue number Z03300, GenScript, USA) every day for 10 days (Sun et al., 2018). Group 6 mice were treated with 1 ng of GM-CSF every day for 10 days … Get A Quote


Oncolytic viruses (OVs) induce antitumor effect by both direct lysis of target cells and eliciting immunogenic response to the virus and ultimately to the target cells. These viruses are usually natural human pathogens. Bacteriophages are natural pathogens of bacteria that do not infect human and have greater advantages in safety, manipulation, and production over human viruses. We constructed an engineered bacteriophage T7 displaying a peptide, which targets murine melanoma cells and harbors a mammalian expression cassette of the cytokine granulocyte macrophage-colony stimulating factor (GM-CSF) in viral genomic DNA. The engineered phage was successfully transduced to B16F10 melanoma cells both and . GM-CSF w... More


anticancer, engineered phage T7, granulocyte macrophage-colony stimulating factor, oncolytic virus, phage display