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Monoclonal Antibodies B38 and H4 Produced in Neutralize SARS-CoV-2

Front Plant Sci. 2020-11; 
Balamurugan Shanmugaraj, Kaewta Rattanapisit, Suwimon Manopwisedjaroen, Arunee Thitithanyanont, Waranyoo Phoolcharoen
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Insect Expression … efficiency. Briefly, RBD of SARS-CoV-2 protein (His tagged RBD produced in Sf9 insect cells, Z03479; Genscript Biotech, United States) was bound to 96-well microplates (Greiner Bio-One GmbH, Frickenhausen, Germany). After … Get A Quote


The ongoing coronavirus disease 2019 (COVID-19) outbreak caused by novel zoonotic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was initially reported in Wuhan city, Hubei Province of China, in late December 2019. The rapid global spread of the virus calls for the urgent development of vaccines or therapeutics for human applications to combat the coronavirus infection. Monoclonal antibodies (mAbs) have been utilized as effective therapeutics for treating various infectious diseases. In the present study, we evaluated the feasibility of plant expression system for the rapid production of recently identified therapeutically suitable human anti-SARS-CoV-2 mAbs B38 and H4. Transient co-expression of ... More


COVID-19, Nicotiana benthamiana, SARS-CoV-2, molecular farming, plant recombinant proteins, plant-produced monoclonal antibody, transient expression