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Dynamic SARS-CoV-2-Specific Immunity in Critically Ill Patients With Hypertension

Front Immunol. 2020-12; 
Qiang Zeng, Yong-Zhe Li, Sheng-Yong Dong, Zong-Tao Chen, Xiang-Yang Gao, Han Zhang, Gang Huang, Yang Xu
Products/Services Used Details Operation
Peptide Synthesis … SARS-CoV-2 Spike glycoprotein peptide pools (SPs,Cat. #RP30020) were obtained from Genscript Biotech, USA … Z03479, Genscript Biotech, USA) as an antigen, and a commercial kit (SARS-CoV-2 Spike RBD ELISA Kit, Cat. #40591-V08H, Sino Biological, China) … Get A Quote


background: The current outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses an unprecedented health crisis. The most common chronic illness among patients infected with SARS-CoV-2 is hypertension. Immune dysregulation plays an important role in SARS-CoV-2 infection and in the development of hypertension; however, the dynamic immunological characteristics of COVID-19 patients with hypertension remain largely unclear. methods: In total, 258 hypertensive patients infected with SARS-CoV-2 were included in this study. CD38HLA-DR and CD38PD-1 CD8 T cells, IFNγCD4 and IFNγCD8 T cells, the titers of IgG, IgM, and IgA against SARS-CoV-2 spike pro... More


CD4, CD8, COVID-19, SARS-CoV-2, T cell, hypertension