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ARRB2 promotes colorectal cancer growth through triggering WTAP

Acta Biochim Biophys Sin (Shanghai). 2021-01; 
Hongguang Liang, Zelong Lin, Youqiong Ye, Rongcheng Luo, Lixian Zeng
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Gene Synthesis … Plasmid construction and transfection. ARRB2 expression plasmid was generated by cloning the full-length open reading frame of human ARRB2 gene (NM_145429.4) into pcDNA3.1-DYK vector (Z03501; GenScript Biotech, Piscataway, USA) … Get A Quote


Colorectal cancer (CRC) is one of the most lethal cancers worldwide. The expression of β-arrestin2 (β-Arr2, ARRB2) in CRC has been well investigated; however, its exact mechanism causing the cancer progression remains unclear. In this study, we discovered that the expression level of ARRB2 was significantly upregulated in CRC as compared to the normal tissues by employing the Cancer Genome Atlas (TCGA) data, western blot analysis, and immunohistochemistry. Furthermore, the level of ARRB2 was correlated with the patients' overall survival by Kaplan-Meier analysis. The higher expression of ARRB2 promoted CRC cell growth, enhanced the cell motility, and blocked cell apoptosis, which is crucial for tumor growth. ... More


ARRB2, WTAP, colorectal cancer, migration, proliferation