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Attenuated Salmonella Typhimurium with truncated LPS and outer membrane-displayed RGD peptide for cancer therapy

Biomed Pharmacother. 2022-09; 
Kang Liang, Zhenyuan Tian, Xin Chen, Mengru Li, Xiaofen Zhang, Xiaoping Bian, Md Kaisar Ali, Qingke Kong
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Gram-negative, facultatively anaerobic bacteria Salmonella Typhimurium is a candidate agent or delivery vector for cancer therapy. Effective targeted therapies in addition to radiotherapy, chemotherapy and surgery have been urgently needed as an alternative or supplement. This study expected to further improve the tumor-targeting ability of Salmonella bacteria through genetic modifications. Based on an auxotrophic Salmonella bacterial strain (D2), we constructed Salmonella mutants with altered LPS length to facilitate displaying the RGD4C targeting peptide on the outer membrane surface of Salmonella. The expression of RGD4C peptide in fusion with OmpA was identified by outer membrane protein extraction and WB d... More


Cancer therapy, LPS, RGD, Salmonella Typhimurium, Tumor targeting