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Zymomonas mobilis ZM4 Utilizes an NADP-Dependent Acetaldehyde Dehydrogenase To Produce Acetate

J Bacteriol. 2022-03; 
Magdalena M Felczak, Michaela A TerAvest
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Zymomonas mobilis is a promising bacterial host for biofuel production, but further improvement has been hindered because some aspects of its metabolism remain poorly understood. For example, one of the main by-products generated by Z. mobilis is acetate, but the pathway for acetate production is unknown. Acetaldehyde oxidation has been proposed as the major source of acetate, and an acetaldehyde dehydrogenase was previously isolated from Z. mobilis via activity guided fractionation, but the corresponding gene has never been identified. We determined that the locus ZMO1754 (also known as ZMO_RS07890) encodes an NADP-dependent acetaldehyde dehydrogenase that is responsible for acetate production by Z. mobilis. D... More


Zymomonas, bioenergy, enzymes, fermentation, metabolism